The search used the names of the pyrogenic substances in Annex G of ISO 10993-11 as listed in Table 1 coupled with one or more of the following keywords: medical device, pyrogen
, ISO 10993, nanomaterial, nanoparticle.
The MAT employing fresh or cryo-preserved human blood was described and validated as an in vitro pyrogen
The Rabbit Pyrogen
(Material Mediated) - ISO Test was performed by Toxikon Corporation in Bedford, Massachusetts, USA.
Any significant increase in the temperature is indicative of pyrogens
. Hitherto the sole alternative was the Limulus amebocyte lysate (LAL) test.
In order to maintain the integrity of such applications, the water used needs to be free from one or more of the commonly encountered contaminants: ions, trace organics, particles, bacteria, pyrogens
, and importantly, nucleases, all of which can have a detrimental effect on resulting data.
The report Pyrogen
Testing Market by Product (Instruments, Services, Kits and Reagents), Application (Pharmaceutical & Biotechnology, Medical Devices, Other), & by Test (In Vitro, LAL, Gel Clot, Turbidimetric, Chromogenic, Rabbit) - Global Forecasts to 2021 provides a detailed overview of the major drivers, restraints, opportunities, current market trends, and strategies impacting the global pyrogen
testing market along with the estimates and forecasts of the revenue and market share analysis.
Infectious fever is the defensive and adaptive reaction that occurs when an organism's immune system comes into contact with exogenous pyrogens
, or pathogen-associated molecular pattern (PAMP).
Leptospira interrogans serogroup Autumnalis, canicola, grippotyphosa, icterohaemorrhagiae, pomona and pyrogens
are used in this study.