Pyrrolidine


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Related to Pyrrolidine: piperazine, Triethylamine

Pyrrolidine

 

tetrahydropyrrole, a heterocyclic compound; a colorless liquid with an ammoniac odor. Boiling point, 87°–88°C; density, 0.8576 g/cm3 at 20°C. It fumes in air and dissolves freely in water. Pyrrolidine is a strong base; it is oxidized to γ-aminobutyric acid by chromic acid.

Pyrrolidine is prepared commercially by hydrogenation of pyrrole or succinimide. The pyrrolidine ring forms a structural molecular fragment of many biologically active substances, including proline, nicotine, cocaine, and certain other alkaloids. Pyrrolidine is used in fine organic synthesis.

References in periodicals archive ?
Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents Tn vivo expression of proinflammatory genes.
The FLG-derived histidine-rich proteins are converted into urocanic acid (UCA) and pyrrolidine carboxylic acid (PCA) by proteases.
Methods: C57BL/6 mice were injected with a 50% glycerin solution at bilateral back limbs to induce rhabdomyolysis, and CLI-095 or pyrrolidine dithiocarbamate (PDTC) was intraperitoneally injected at 0.5 h before molding.
This considerably corresponded to pyrrolidine ring vibration of proline and hydroxyproline as described by (Muyonga et al.
These different behaviors can be attributed to the distinct molecular structure of used polymers (PVP and PVA), since PVA monomers present relative simple chemical structure, with a pendant hydroxyl group, whereas PVP presents a pyrrolidine ring attached to the carbon skeleton.
After the addition of 10 ng [2H]MVL, MVL was extracted using diethyl ether; the ether phase supernatant was collected and evaporated to dryness under nitrogen, and then 100 [micro]L volume of toluene and 20 [micro]L of 1-(2-aminoethyl) pyrrolidine were added to the residue of the ether extract and incubated at 55[degrees]C for 60 min.
Indeed, monocyte THP-1 cells that produced caspase 1 (i.e., showed NLRP3 inflammasome activation) in response to asbestos or silica showed a blunted response in specific knockdown of NADPH oxidase subunit p22phox or when treated with ROS scavengers (N-acetylcysteine and ammonium pyrrolidine dithiocarbamate) [11].
Zhang et al., "Pyrrolidine dithiocarbamate inhibits nuclear factor-xB pathway activation, and regulates adhesion, migration, invasion and apoptosis of endometriotic stromal cells," Molecular Human Reproduction, vol.
Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages.
(13) first reported the risk of HVOD caused by rooibos tea containing pyrrolidine alkaloids (PAs) in Jamaica and Barbados.
the fragmentation pattern of vinyl pyrrolidine. Also mass fragmentation of the peak at retention time 1.39 shows the fragmentation pattern of VP.
Pyrrolidine 1-nitroso- (NPYR) is an important hepatocellular carcinogen frequently present in the environment [44] it is found at six sampling sites most of which are sewerage drains (Table 9).