Quinacrine can be added to either hydroxychloroquine or chloroquine to achieve improvement in patients who don't respond to a single antimalarial agent.
Lupus panniculitis treated by a combination therapy of hydroxychloroquine and
quinacrine.
One group reported inhibition of prion propagation by
quinacrine and chlorpromazine in vitro.
Safety and efficacy of
quinacrine in human prion disease (RION-1 study): a patient preference trial.
Four of the most studied drugs are the analgesic flupirtine, intraventricular pentosan polysulphate, amantadine (a dopaminergic drug with anti-influenza virostatic actions) and the anti-malarial,
quinacrine.
Bolte J, Demuynck C, Lhomme F, Lhomme J, Barbet J, Roques BP Synthetic models related to DNA intercalating molecules: comparison between
quinacrine and chloroquine in their ring-ring Interaction with adenine and thymine.
Topical treatments of leishmaniasis are numerous and include
quinacrine, miconazole, clotrimazole, chlorpromazine, amphotericin, garlic cream and ZHE cream (22-27).
During early part of the 20th century, a series of organic compounds (beginning with methylene blue) were evaluated, which led to the discovery of pamaquine and
quinacrine and ultimately chloroquine, a 4-aminoquinoline.
Theories analogous to those offered to explain a similar syndrome induced by
quinacrine have been suggested including prostaglandin E antagonism (Lindenmayer & Vargas 1981) and the induction of cholinergic imbalance (Davis & Berger 1978) but these hypotheses have yet to be formally evaluated.
An RCT in Cuban children 5 to 15 years of age found no difference in clinical cure rate between a 5-day course of mebendazole and more traditional therapy with
quinacrine.
Antimicrobial therapy options for giardiasis include albendazole, furazolidone, metronidazole, nitazoxanide, paromomycin,
quinacrine, and tinidazole.
A possible pharmacological explanation for
quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie.
