quinidine


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Related to quinidine: quinine, Quinidine sulfate

quinidine

(kwĭn`ĭdēn'), heart muscle relaxant used to maintain regular heart rhythm patterns. It is an alkaloidalkaloid,
any of a class of organic compounds composed of carbon, hydrogen, nitrogen, and usually oxygen that are often derived from plants. Although the name means alkalilike, some alkaloids do not exhibit alkaline properties.
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 chemically similar to quininequinine
, white crystalline alkaloid with a bitter taste. Before the development of more effective synthetic drugs such as quinacrine, chloroquine, and primaquine, quinine was the specific agent in the treatment of malaria.
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 and, like quinine, occurs naturally in some species of cinchona trees. Quinidine slows the rate of blood flow in heart chambers and lowers the excitability of the muscle. Quinidine is a general relaxant of smooth muscle and acts as a dilator of larger blood vessels. It has also been used to reduce fever and to treat malaria. Synchronized electric shock has largely replaced quinidine as a method of establishing more normal heart rhythms.

quinidine

[′kwin·ə‚dēn]
(organic chemistry)
C20H24N2O2 A crystalline alkaloid that melts at 174-175°C (345-347°F) and that may be derived from the bark of cinchona; used as the salt in medicine. Also known as β-quinine.
References in periodicals archive ?
With quinidine, we can use smaller dosages of dextromethorphan" than might be required if the drug were used by itself and thereby avoid the lethargy that could occur in patients who might require larger dosages of dextromethorphan without quinidine, he said in an interview
Molecular docking of cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA dextromethorphan, quinidine to CYP2D6 was performed using the three dimensional (3-D) crystal structure of substrate free CYP2D6 (PDB code 2F9Q) obtained from the Protein Data Bank (Rowland et al.
Quinidine is associated with a high incidence of gastrointestinal adverse effects, with loose bowel movements and diarrhea being among the most common.
Patients placed on intravenous quinidine should have constant cardiac monitoring because the drug can cause widening of the QRS complex, widening of the QT interval, and hypotension.
Musks and the P-gp inhibitor reference compounds quinidine and verapamil caused a dose-dependent increase in accumulation of rhodamine B in mussel gill tissue, indicating an inhibition of efflux transporter activity.
Among the many natural products found beneficial in treating cardiac problems are digitalis, quinidine.
The birds that were also given clay took up only about one-third as much quinidine.
Since diaphragmatic cramp is not amenable to the normal methods of muscle cramp treatment, ie, massage and stretching, the only treatment available is quinidine and analgesia.
Co-administration of low doses of quinidine has been shown to inhibit cytochrome P4502D6 and lead to increased propafenone plasma concentrations in individuals who are extensive metabolizers (8).
Antiarrhythmics -- quinidine, Pronestyl/Procan, Norpace, Tonocard, Tambocor, Mexitil, Cardarone, Enkaid, DecaBid
The drugs most commonly involved were the antibiotics tetracycline and doxycycline, time-release potassium chloride, quinidine, aspirin, and nonsteroidal anti-inflammatory drugs (NSAIDs), such as Motrin, Feldene, and Indocin.