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any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.
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A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.


A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
All family members (the patient's wife and his two sons) were administered PEP with rabies immune globulin and vaccine.
* Including withholding human rabies postexposure prophylaxis (i.e., rabies immune globulin and vaccine), induction of coma, respiratory protection, electroencephalogram burst suppression with benzodiazepines and barbiturates, antivirals (e.g., amantidine and ribavirin), and ketamine (10).
No specific course of treatment for rabies in humans has been demonstrated to be effective, but a combination of treatments, which might include rabies vaccine, rabies immune globulin, monoclonal antibodies, ribavirin, interferon-alpha, or ketamine, has been proposed (2).
In addition, if rabies immune globulin (RIG) * was not administered with the first dose of vaccine and it has been <7 days since the first dose of vaccine, RIG should be administered at this time.
Because the patient reported to the ED at an early stage of rabies infection, with predominantly local symptoms near the bite site, rabies vaccine, rabies immune globulin, ribavirin, and interferon-alpha were administered on the day of admission; a second dose of rabies vaccine was administered 3 days later.
Rabies immune globulin, vaccine, and acyclovir were administered.
On September 29, the resul ts of the rabies tests were positive, and rabies immune globulin and vaccine were administered to the patient.
On the basis of telephone calls to petting zoo visitors who signed the guest register and provided contact information, approximately 150 of the 400 persons were exposed to the bear's saliva and need to obtain vaccine and rabies immune globulin. Public health authorities are attempting to contact petting zoo visitors by telephone and the Internet.