Racemase


Also found in: Medical.

racemase

[′ras·ə‚mās]
(biochemistry)
Any of group of enzymes that catalyze racemization reactions.

Racemase

 

any one enzyme of the isomerase class that catalyzes the reversible interconversions of stereoisomers having one asymmetric carbon atom. Racemases include the enzymes that catalyze the interconversion of L- and D-amino acids, Land D-hydroxy acids, and the derivatives of these acids; for example, the interconversion of L- and D-alanine is catalyzed by alanine racemase, and the interconversion of L- and D-lactic acid by lactate racemase.

The racemases of amino acids are conjugated proteins having pyridoxal phosphate as the coenzyme. Thus far, the bacterial racemases of alanine, methionine, proline, glutamic acid, lysine, and threonine having been the most carefully studied. The racemase of lysine is used in the industrial production of L-lysine.

References in periodicals archive ?
Keywords: Alphamethylacyl-CoA racemase (AMACR), Adenocarcinoma prostate, Immunohistochemistry.
In addition, the cytoplasm in HGPIN is typically positive for [alpha]-methylacyl coenzyme A racemase immunostain.
Alpha-methylacyl-CoA racemase (AMACR), a recently discovered positive IHC marker for prostatic carcinoma is being increasingly used in combination with routine H and E staining and negative basal cell marker p63, especially in morphologically difficult needle biopsies of prostate.
methylacyl-CoA racemase (AMACR), has become a useful biomarker in the diagnosis of prostate adenocarcinoma1.
The immunostaining results were almost the same as the first specimen: SMA (+), CD117 (+) (1+) 100%, CD34 diffuse (+) 100%, smoothelin (-) some isolated cells, [alpha]-methylacyl coenzyme A racemase (-), Keratin AE1/AE3 mildly-focal (+), S100 (-), estrogen and progesterone receptor (-), desmin focal (+).
2014) reported that chronic nature of Brucella is due to some virulence factors, among which are the immunomodulatory proteins such as PrpA (proline racemase protein A), involved in the establishment of the chronic nature of the infectious condition.
Peroxisomal disease Peroxisome biogenesis disorders (PBDs) Zellweger spectrum disorders Zellweger syndrome (ZS) Neonatal adrenoleukodystrophy (NALD) Infantile Refsum disease (IRD) Rhizomelic chondrodysplasia punctata (RCDP) Single-enzyme deficiencies Adrenoleukodystrophy (ALD) Acyl-CoA oxidase deficiency D-Bifunctional protein deficiency 3-Ketoacyl-CoA thiolase deficiency Refsum disease (phytanyl-CoA hydroxylase deficiency), [alpha]-Methylacyl-CoA racemase deficiency Hyperoxaluria type I (alanine glyoxylate aminotransferase deficiency) Mevalonate kinase deficiency Glutaric aciduria 3 (glutaryl-CoA oxidase deficiency) Acatalasemia Table 3.
Is triple immunostaining with 34PE12, p63, and racemase in prostate cancer advantageous?
Patrikar, "Diagnostic utility of p63 and a-methyl acyl Co A racemase in resolving suspicious foci in prostatic needle biopsy and transurethral resection of prostate specimens," Journal of Cancer Research and Therapeutics, vol.
Another paper based on a 15 cases series reported results that indicate a distal tubular cell profile (positive expression of EMA, AE1/AE3, CK7, CK19, Ecadherin, alpha-methylacyl-CoA racemase (AMACR), and negative for CD10) [8].
v) The epithelial component of the lesions was positive in all cases for pancytokeratin (AE1/3) and racemase and demonstrated variable cuff of type IV collagen surrounding the tubules.