racemate

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racemate

[′ras·ə‚māt]

(organic chemistry)

An equimolar mixture of the two enantiomers (+ and -, or R and S) of a substance; it is optically inactive.

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But the practice of first patenting a racemate and then separately patenting an enantiomer years later is problematic.

Expecting the unexpected

The reason that the CHMP determined that eszoplicone should not be granted new active substance status was because Sepracor failed to prove relevant and clinically meaningful differences between eszopiclone and the racemate of which it was the active enantiomer, zopiclone in an adequate planned clinical trial with direct head to head comparison.

EU legal & regulatory update--October 2011

Five of Hurricane Run's black-type winners broke through at stakes level from September onwards, namely Mohedian Lady (who set a course record when running away with the Princess Royal Stakes at Newmarket), Freedom, Charleston Lady, Barbican and Racemate.

Hurricane crop worth watching next season

130) When the racemate of a chiral compound is disclosed in the prior art, patent examiners and, ultimately, the courts must determine whether a separated and isolated enantiomer is obvious over its racemate.

Deuterated drugs: unexpectedly nonobvious?

Enzymatic resolution of a racemate is also a widely used method to obtain enantiomerically enriched compounds [6, 7].

Preliminary study on enzymatic kinetic resolution of isopropylidene glycerol

The use of enantiomerically pure DOTAP Chloride shows enhanced adjuvant activity compared to the racemate.

PDS BIOTECHNOLOGY LICENSES MERCK EPROVA'S DOTAP CHLORIDE

In preparative separations, the addition of IC to the immobilized Daicel range increases the potential to find a highly productive separation that matches the column selectivity to the solvent that best suits the racemate.

Columns undertake new, improved and complementary separations

Each of these compounds exists in the solid as a racemate of right- and left-handed helices, in which the M(hfac)[.

Saturday presentations

vittatum IS-7 were the only species that showed greater sensitivity to a specific isomer or the racemate of fipronil.

Alabama Academy of Science Symposium, 2006 "Southeastern Society for Environmental Toxicology and Chemistry" Annual Meeting, Troy University

Thus, there exists a possibility that smaller racemate moleculs, which cannot be resolved on [beta]-CD bonded phases, can be resolved on [alpha]-CD phases [9].

Chemically bonded [beta]-cyclodextrin stationary phase for liquid chromatographic separation of substituted aromatic compounds/Asendatud aromaatsete uhendite vedelikkromatograafiline lahutamine [beta]-tsuklodekstriinsel statsionaarsel faasil

John's Wort Decreased effect Stimulation of cytochrome 2C9, which is responsible for metabolizing a major warfarin racemate Acerola/Vitamin C Antagonistic effect Excessive amounts of vitamin C associated with a procoagulant effect Fish Oils Synergistic effect Presumably through a decrease in platelet aggregation * Condensed from Natural Medicines Comprehensive Database, 2001 Table 4.

Dietary supplements: applying the knowledge. (Pharmacology Update)

Celgene was assigned a broad United States patent on the "pulse release" formulation of both d-methylphenidate and the racemate late last year.