Data Source: First randomized
controlled trial comparing robotic-assisted and laparoscopic hysterectomy in 53 women.
However, he was quick to warn that such epidemiological studies should not change clinical recommendations; only randomized
controlled trials can do that.
During the randomized
phase of the trials, the mean all-cause mortality was significantly lower for the active treatment group (odds ratio, 0.84; P = .0006), as was cardiovascular mortality (0.72; P less than .001).
Baseline demographics were balanced between the placebo and acyclovir groups, except that babies randomized
to acyclovir in the CNS study were smaller at delivery and lighter at the time of enrollment than were those randomized
to placebo; acyclovir-treated babies in the SEM study were lighter at enrollment, as well, he said.
ASSERT is an ongoing 96-week randomized
trial, which means that study participants are randomly assigned to take Epzicom or Truvada--both with Sustiva (efavirenz)--as their first antiretroviral combination.
In general, there were more placebo patients over the respective thresholds, compared to patients randomized
to receive rintatolimod.
When we read reports that are given the highest evidence ratings, and when we see that they are prospective, randomized
trials, many of us are inclined to believe the results.
The development of the randomized
trial design has been one of the most important, major advances in medicine.
Results: In the randomized
studies, the Iscador group of patients with endometrioses and cervix dysplasia showed significantly lower incidence of cancer and a tendency to longer tumour-related survival periods; in the case of myomas no significant effects were found.
It's clear that the randomized
controlled trial is a powerful tool for determining the usefulness of a discrete intervention such as a medication.
Results: Subjects randomized
to sulfonylurea/placebo, as opposed to those randomized
to sulfonylurea/CrPic, had a significant increase in body weight, percent body fat, and total abdominal fat.
Proposed Sample Size: Stage 1: Up to 12 patients randomised to open-label active treatment at 1 centre Stage 2: 30 in total, randomized
in a 1:1:1 treatment allocation