to suggest that CpCo[(NO).sub.2] may be the initially formed intermediate; they subsequently provided kinetic and spectroscopic evidence for CpCo[(NO).sub.2] as a reactive intermediate
Summary: A base-catalyzed one pot reaction has been developed for the synthesis of 2-(1H-indol-3-yl)- acetamides via coupling of 1,1-carbonyldiimidazole with 2-(1H-indol-3-yl) acetic acid resulting in the formation of a reactive intermediate
which on treatment with different substituted anilines afford 2-(1H- indol-3-yl)-acetamides in good yield.
Metabolism/clearance studies assess a drug candidate's stability in microsomes/hepatocytes; and human cytochromes P450 (CYP) isoform involvement, inhibition, induction and reactive intermediate
Enzyme-free reduction of nitro-aromatic compounds and the sequence of reactions in the reduction of nitro functional group result in the formation of very highly reactive intermediate
Biological Reactive Intermediate
Conference VII: BRIs and Human Health and Disease.
The advantage of this mechanism of energy dissipation is that no reactive intermediate
species and no photolytic decomposition products are formed on the skin.
The nature of this reactive intermediate
is unknown at present.
A key is to monitor the excited states and the reactive intermediate
species formed upon absorption of a photon.
Chemistry, edited by Platz, looked at the chemistry of reactive intermediates
commonly encountered in mechanistic organic chemistry, and the 10 studies here expand the coverage to include intermediates centered on silicon, germanium, and tin; tetrahedral intermediates; and such topics as quantum mechanical tunneling, conical intersections, and combustion chemistry.
To understand the exposure-response relationship, it is necessary to understand the relationship between environmental concentrations of a compound and a measure of body burden or a biomarker that can be a reactive intermediate
, a stable metabolite, or a macromolecular adduct.
Chromate reduction is accompanied by the generation of highly reactive Cr(V), a reactive intermediate
, and reactive oxygen intermediates which can cause DNA damage including intra- and interchromosomal deletions and base substitutions.