We hope that further studies performed on larger number of patients--reactive thrombocytosis- and controls, additionally including thrombo-cythemic disorders, with the possibility of encountering higher platelet counts and analyzing additional criteria that could influence viscosity can illuminate the dark spots of current clinical practice in reactive thrombocytosis which seems innocent at the present.
Postsplenectomy reactive thrombocytosis. Proc (Bayl Univ Med Cent) 2009; 22 (1): 9-12
Reactive thrombocytosis and stroke following cardiopulmonary bypass surgery: Case report on three patients.
Hang and Teu (19) found that 78% cases of reactive thrombocytosis may be due to infections.
700-900 x [10.sup.9]/L has been found in approximately 6-8% of children with reactive thrombocytosis and only 0.5-3% have platelet count > 1000 x [10.sup.9]/L.1920 Fouzas S et al (21) studied 408 infants and found 25.2% had SBI.
Evidence of an increased in vitro thrombotic tendency in patients with reactive thrombocytosis is of paramount importance in proving the cause and effect relationship between reactive thrombocytosis and thromboembolism.
After obtaining Royal Perth Hospital Ethics Committee approval (EC2009/098), a total of 48 patients with reactive thrombocytosis, defined by platelet count >500 x [10.sup.9]/l, and 55 randomly selected patients who did not have thrombocytosis in the intensive care unit (ICU) were recruited.
The relationship between reactive thrombocytosis and evidence of having a strong in vitro thrombotic tendency (MA >80 mm) was analysed by multivariable logistic regression after adjusting for clinical and laboratory variables that were associated with a P value <0.25 in the univariable analyses.
A total of 54 patients with reactive thrombocytosis were recruited during the study period between July 2010 and June 2011.
Patients with reactive thrombocytosis were significantly more likely to demonstrate evidence of an increased in vitro thrombotic tendency than were patients in the control group without evidence of reactive thrombocytosis (MA >74 mm: 77 vs 29%, P=0.001, and mean MA 77 vs 69 mm, mean difference 8 mm, 95% confidence interval 4.9 to 10.9, P=0.001, respectively) (Table 2).
is the most common type of thrombocytosis.
(4) Nonstandard abbreviations: RT, reactive thrombocytosis
; MPD, myeloproliferative diseases; ET, essential thrombocythemia; PV, polycythemia vera; CML, chronic myeloid leukemia; PLT, platelet count; MPV, mean platelet volume; PDW, platelet distribution width; and MF, myelofibrosis.