reading frame


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reading frame

[′rēd·iŋ ‚frām]
(cell and molecular biology)
A nucleotide sequence that starts with an initiation codon, partitions the subsequent nucleotides into a series of amino acid-encoding triplets, and ends with a termination codon.
References in periodicals archive ?
They are enveloped, partially double-stranded DNA viruses with a small circular genome ([approximately equal to]3 kb) and at least 3 open reading frames (ORFs) (1).
SPLUNC1 cDNA-ORF contains one long open reading frame of 768 bp from 64 nt to 831 nt.
None of the dominant haploytpes included any stop codons but there were three minor haplotypes (five clones) of the nad2 locus, and two minor haplotypes (two clones) of the coI locus that had stop codons in the expected open reading frame.
The contig Sl-Ago1 (GenBank KF717084, Table 2) was 2,805 bp long, with an open reading frame encoding 928 amino acids.
Analysis of the fusion sequence revealed an open reading frame encoding a protein of 445 amino acids with predicted molecular mass of about 50 kDa without glycosylation (ExPASy).
sup][4],[5] Skipping of exon 8 results in a shift in the reading frame and thereby causes premature truncation of the encoded protein.
In case of the frame-shifting deletion of exon, modifying the splicing of mRNA allows the exclusion of one or several additional exons and the restoration of a reading frame (Figure 5).
His miRNA switches consist of synthetic mRNA sequences that include a recognition sequence for miRNA and an open reading frame (ORF) that codes a desired gene, such as a regulatory protein that emits fluorescence or promotes cell death.
Genotype-phenotype correlation studies in D/BMD have shown that the disease severity is influenced not so much by the size of the mutation, as by: (i) the location of the mutation in relation to the critical functional domains of the dystrophin protein; and (ii) the effect of the mutation on the DNA translational open reading frame (ORF).
Molecular analysis of partial open reading frame V1 sequences showed that PiCV strains detected in feral pigeons share high nucleotide and amino acid sequence identities with PiCV strains detected in ornamental, racing, meat, and feral pigeons.
What we know and love, reading Frame, are the dizzying effects of re-enactments, mimicry and echoing; the work patterning like the figure in a trick-mirror box infinitely, recognisably, yet increasingly estranged.
Other mutation types such as a change from an amino acid to a stop codon, a mutation that results in a shift of the reading frame, and changes that affect the process of splicing, result in premature termination of translation with possible nonsense-mediated mRNA decay and are highly likely to be deleterious.