An exceptional complex chromosomal rearrangement
(CCR) with eight breakpoints involving four chromosomes (1;3;9;14) in an azoospermic male with normal phenotype.
Our working hypothesis is that in infants the MLL rearrangement
occurs in a developing blood cell, a prenatal progenitor cell, which requires fewer additional mutations to fully transform into leukemia.
The purpose of this investigation was design evaluation of an auxiliary approach to increase sensitivity of diagnosis and to apply BIOMED-2 molecular gene rearrangements
assays on FFPE tissue in HL samples.
Because current NIPT methods rely on the detection of deviations in the representation of a particular chromosome or subchromosomal region, genomic aberrations resulting from copy-number-neutral rearrangements
, such as balanced translocations, have proven to be more challenging and have yet to be detected noninvasively from ccf DNA in pregnant plasma.
Because not all cores with minute cancer foci or the highest Gleason scores were selected from each case, we did not formally compare rates of ERG staining in minute versus nonminute cancers or across Gleason scores, which has been addressed in prior studies using FISH for ERG rearrangement
Major Finding: Identification of individualized tumor-specific rearrangements
can be used to assess response to treatment and detect recurrence of solid lesions
Based on the information available we propose that in our case the chromosomal rearrangement
could have separated the promoter from a distant regulatory element, or might have juxtaposed a gene with a regulatory element from another gene, or brought a gene and its regulatory element close to another gene generating competition for the regulatory element between the two genes, and finally, the rearrangement
could have given rise to a position effect variegation (PEV) (14,15).
is a synthetically useful reaction for the preparation of hydroxyaryl ketones, not only in laboratory but also in industrial processes .
71) There is undoubtedly a correlation between the rates of speciation and chromosome rearrangement
While the sequence product of this kind of technology would lack some important information, such as information about genomic rearrangements
, it would nevertheless potentially be available more rapidly and produce data of great value for certain uses in studying disease etiology and in individualized medicine.
They found that high-heat milk treatment and low incubation temperatures are less likely to lead to a rearrangement
of the network.
The specimen was sent to the Armed Forces Institute of Pathology in Washington, DC, for T-cell receptor (TCR) gene rearrangement