As a proof-of-principle study, our cases were limited to patients with a diagnosis of FL but this approach can be applied to a wider range of lymphoproliferative disorders as long as the lymphoma in question carries a rearrangement
that can be detected by a given NGS assay.
Key words: Chronic myeloid leukaemia, flourescent in situ hybridization (FISH), BCR/ABL gene rearrangement
Hence there are no clear results about rearrangement
ratios in the Turkish population.
A [chi square] test was used to correlate CD99 positivity with the presence of EWSR1 rearrangement
. The results are considered significant when p < 0.05.
We presented a rare case of SCC with ALK rearrangement
, which showed a remarkably positive response to alectinib.
FISH analysis using a KMT2A locus-specific dual-color DNA probe (Vysis LSI MLL Dual Color, Break Apart Rearrangement
Probe, Abbott Laboratories, IL, USA) was used to characterize the partial 5' duplication and 2 other normal KMT2A alleles (Figure 1).
As a result, tumors often contain chromosomal rearrangements
, which are places where genes are cut and pasted back together in ways that they shouldn't be.
In this study, we introduced IGH and IGK-Kde genes rearrangement
as an independent diagnostic and prognostic factors in Tunisians with B lineage leukemias.
The findings were published earlier this year in the Journal of Organic Chemistry, including rearrangement
step classifications and a new table listing the energy barrier heights for various steps.
Herein, we have studied on the rearrangement
of 5-methyl-3-nitrosoindolizine derivatives under alkaline conditions.
In these patients, loss of fertility is mainly caused by the high prevalence of gametes that have lost or gained chromosome material as a result of the rearrangement
of the derivative chromosomes or a generation of a recombinant chromosome.
Validation of immunoglobulin gene rearrangement
detection by PCR using commercially available BIOMED-2 primers.