In contrast, the reassortant virus
expressing WM1-STM2 protein replicated differently from the virus with the full-length M gene derived from the ST strain.
The other 7 gene segments in this human-like H3 reassortant virus
were of the same lineages as those segments found in the cluster IV-A virus (Table 2).
Most recently, a novel reassortant virus
of subtype H5N8 clade 18.104.22.168 was reported in Russia and further spread to many countries in Europe, Asia, and the Middle East (4,5).
A previous study reported that A/environment/ Guangdong/GZ693/2015 (H5N6), hereafter referred to as GZ693/2015(H5N6), is a 7:1 gene reassortant virus
between H5N6 HPAIV and LPAIVs found in southern China (7).
A BLAST search (https://blast.ncbi.nlm.nih.gov/) suggested that QH-H5N8 is a reassortant virus
(online Technical Appendix Table 1) and that the HA, neuraminidase (NA), and nonstructural protein (NS) genes of QH-H5N8 share high nucleotide identity (>99.1%) with those of the H5N8 virus that circulated among poultry in eastern China in 2014 (A/duck/Eastern China/S1109/2014[H5N8]).