Characterization of the balance
reciprocal translocation: The characterization of the balance
reciprocal translocation was attained by BAC FISH.
(8) Our report emphasizes the clinical presentation of a balanced
reciprocal translocation t(X;1).
Chromosome analysis by spectral karyotyping of spermatozoa from an oligoasthenozoospermic carrier of a 10; 21
reciprocal translocation. Hum Cell 2011;24:146-9.
(10) The translocation trisomy 21 present in Down syndrome patients can be created spontaneously de novo during gametogenesis in one of the parents or it can be inherited from parents' carrier of Robertsonian translocation or of
reciprocal translocations.
A balanced
reciprocal translocation is an exchange of material between two nonhomologous chromosomes, without loss or gain of material and balanced translocation carriers are usually healthy and phenotypically normal.
A
reciprocal translocation does not change the amount of chromosomal material, but only the order of the genetic material.
CML is caused by a so-called '
reciprocal translocation' between chromosomes 9 and 22, resulting in the "Philadelphia chromosome," a well-known marker for CML.
Unlike melanoma, clear cell sarcoma has a
reciprocal translocation t(12:22) resulting in the fusion of EWS RNA-binding protein 1 (EWSR1) with activating transcription factor 1 (ATFT) in more than 90% of cases.
After data filtering, we identified 2 putative
reciprocal translocation events.
(1,2) Morphologically classified as AML-M3 by the French-American-British (FAB) classification, APL is typically characterized by neoplastic proliferation of cells in the bone marrow with a promyelocytic phenotype and the balanced
reciprocal translocation t(15; 17) (q24.1; q21.2), which results in the expression of the promyelocytic leukemia (PML)-retinoic acid receptor-[alpha] (RARA) fusion protein.
Confirmation of the chromosomal translocation: Spectral karyotyping (SKY) was performed which showed the balanced
reciprocal translocation (BRT) involving only chromosomes 18 and 22.
Her husband had a balanced
reciprocal translocation between the long arm of chromosome 10 and the short arm of chromosome 22, 46,XY,t(10; 22)(g24.1;p11.2).
