relapse


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relapse

the return of ill health after an apparent or partial recovery

Relapse

 

a new exacerbation of a disease during remission after an apparent recovery. In the case of a latent chronic infection, for example, brucellosis, pneumonia, and erysipelas, a relapse may be caused by inadequate immunity, chilling, or the supervention of a secondary infection. It may also be caused by a faulty diet, for example, with colitis, or by the cyclical nature of the disease itself (malaria, relapsing fever). The pathogenic microflora of the body is usually activated as a result of a relapse. A repeated infection caused by the same microorganisms is called a reinfection.

The pathogenesis of a relapse of a noninfectious disease is caused by shock, for example, with eczema, by vascular disorders, by regular malignant growth, and by inadequate treatment, for example, by the incomplete removal of a tumor. The pathogenesis of a relapse is sometimes unknown, for example, with familial Mediterranean fever and schizophrenia.

The clinical symptoms of a relapse may resemble or differ from the onset of a disease as a result of both the nature of the disease and the prescribed treatment. A relapse is sometimes more severe than the first attack of a disease and is more difficult to treat, as in the case of a relapse of acute leukemia. A relapse may be accompanied by complications, for example, intestinal bleeding in typhoid. Relapses are common to some diseases, for example, chronic dysentery. Treatment and preventive methods for relapses are usually the same as for the original disease.

A. A. SMIRNOV

References in periodicals archive ?
"Plucking an exclusion for risk of relapse out of thin air would undermine the integrity of an ERISA plan."
The study included patients aged 18 years or older at the time of participation with a confirmed MS relapse, as determined by the investigator, and willingness to comply with all procedures and assessments.
The taxonomy of relapse is a hierarchical system with three levels (see Table 3).
Incidence and risk factors for central nervous system relapse in children and adolescents with acute lymphoblastic leukemia.
Children treated with fluticasone propionate had a 2.7-fold lower risk of relapse than that of children treated with vehicle; 7 of 26 (27%) in the fluticasone propionate group and 13 of 23 patients (57%) in the vehicle group experienced relapse, the investigators wrote.
JI: It's really very easy to relapse by treating it is a comfort zone.
In this study, ZYN002 reduced relapse provoked by stress and drug cues, and reduced anxiety and impulsivity in the drug-experienced rats without sedative and nonspecific effects on motivation.
Kaplan-Meier analysis and the log-rank test also showed that the first relapse was significantly earlier in the frequent relapsers than in the infrequent relapsers (Figure 2).
Thus, he had MS as the only manifestation of posttransplant AML relapse. He received induction treatment with amsakrin 150 mg/[m.sup.2] once daily on days 1-5, etoposide 110 mg/[m.sup.2] once daily on days 1-5, and cytarabine 200 mg/[m.sup.2] as daily continuous infusion on days 1-5; peripheral blood and bone marrow examination were consistent with complete hematological remission, and MRI showed regress of the epipharyngeal tumor.
CNS relapse occurred in 17 (81%) patients within six months after completion of therapy.
They have also identified two distinct stem cell like populations from which relapse can arise in different patients in this aggressive cancer that they previously showed starts in blood stem cells in the bone marrow.