renal clearance


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renal clearance

[¦rēn·əl klir·əns]
(physiology)
The volume of blood plasma completely cleared of a particular substrate by the kidneys per unit time, a measure of kidney function.
References in periodicals archive ?
Kidney functions of cefixime were estimated after calculation of diuresis, renal clearance of cefixime and creatinine, clearance ratio and cumulative percentage of dose excreted.
Augmented renal clearance in the ICU: Results of a multicenter observational study of renal function in critically ill patients with normal plasma creatinine concentrations.
Analysis of values and changes in renal clearance revealed that the majority of patients had an improvement in renal function, with the exception of two patients with a postoperative clearance of <60 ml/min (36.21 and 41.5 ml/min, resp.), knowing that these 2 patients had some degree of kidney failure before surgery (preoperative clearance of 60.5 and 59.5 ml/min, resp.).
It is mainly filtered by the kidney and achieved 94% of renal clearance calculated using [sup.51]Cr-EDTA in previous literatures [9, 19-21].
Marco Taddio and colleagues describe the pharmacokinetic modelling of new PET radiotracers in mice and evidence how transporter inhibition by cyclosporine decreases their liver clearance while increasing the renal clearance. In rats, Fabien Caille and colleagues describe the labelling of metoclopramide and show that its transporter-mediated plasma clearance into hepatocytes is saturable and not modified by the P-glycoprotein inhibitor tariquidar.
Relationship of serum cystatin C to peritoneal and renal clearance measures in peritoneal dialysis: a cross-sectional study.
Other home medications may have accentuated hypoglycemia: digoxin and ranitidine by competing with metformin for common renal tubular transport systems and furosemide which may increase metformin plasma levels without altering renal clearance. (2) Ranitidine may also increase serum concentrations of glipizide.
One could speculate that large prolactin isoforms accumulate in patients with a reduced renal clearance. However, hyperprolactinemia in patients undergoing renal replacement therapy (RRT) does not consist abundantly of macroprolactin (>50 kDa) isoforms [1].
Higher doses including those above therapeutic levels carry a higher risk of adverse events including hemorrhagic complications given the increased reliance on renal clearance [4].
Different sets of experimental animals were used for biochemical determinations, renal clearance studies, preparation of homogenates (H), and apical membranes (AM) for Western blotting studies, immunohistochemical studies, and mRNA isolation (for RT-PCR studies).
Pathogenetic factors include alterations in intestinal absorption, plasma protein binding, hepatic extraction ratio, liver blood flow, portal-systemic shunting, biliary excretion, enterohepatic circulation, and renal clearance. The global liver diseases therapeutic drugs market report estimates the market size (Revenue USD million - 2013 to 2020) for key market segments based on the drug classes (antiviral, chemotherapy, Corticosteroids, immunoglobulins, immunosupressants, targeted therapy drugs and vaccines), therapeutic applications (alcohol induced liver diseases, autoimmune liver disorders, hepatocellular carcinoma, NAFLD, viral or hepatitis liver disorders), and forecasts growth trends (CAGR% - 2016 to 2020).