The protective effect of Montelukast against skeletal muscle ischemia reperfusion injury
: An experimental rat model.
Protective effect of preconditioning and adenosine pretreatment in experimental skeletal muscle reperfusion injury
. Br J Surg 1999; 86: 916-22.
The mechanisms underlying lethal reperfusion injury
mainly include: (a) oncosis, (b) hypercontracture, (c) large generation of ROS, (d) over inflammatory response, and (e) opening of MPTP.,,
In the treatment of ICVD, the reconstruction of blood flow or enhancement of the blood supply in the ischemic region is essential for the repair of ischemic brain tissue, but it also poses a problem of reperfusion injury
. Other available therapeutic approaches for ICVD, such as thrombolytic tissue plasminogen activator, have a limited therapeutic window.
Mathie, "Attenuation of reperfusion injury
by renal ischaemic preconditioning: The role of nitric oxide," BJU International, vol.
This may shed lights on a novel mechanism of XXMD treatment against focal cerebral ischemia and reperfusion injury
Yellon, "New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury
Salvage Kinase (RISK)-pathway," Cardiovascular Research, vol.
Kvietys, "Reperfusion injury
and reactive oxygen species: the evolution of a concept," Redox Biology, vol.
Attanasio et al., "Biliverdin protects against liver ischemia reperfusion injury
in swine," PLoS One, vol.
These changes suggest that the soleus muscle adapts well to reperfusion injury
to maintain its function and mechanism of contraction (Table 1).
Detorsion operations to protect the ovarian reserve result in reperfusion injury
, which worsens the tissue damage (Li & Jackson, 2002).
Due to the high mortality rate of RAAA, new treatments are required to prevent post-operative reperfusion injury
which leads to the death of RAAA patients.