Recent studies such as Women's Health Initiative (WHI) and Heart and Estrogen/Progestin Replacement Study
(HERS) have failed to deem beneficial impacts of estrogen combined with progestin and exogenous estrogen in prevention of cardiovascular disorders.
It's unclear why the previous joint replacement study
showed a successful reduction in costs under BPCI, while the new study did not.
In the Heart and Estrogen/ progestin Replacement Study
(HERS) II, (2) the unblinded 2.7-year follow-up to the HERS trial, women originally assigned to EPT had a 3.3-fold higher rate of ventricular arrhythmia requiring resuscitation than women assigned to placebo (HR, 3.30; 95% CI, 1.08-10.10).
This review, which adapts and expands an earlier review (5), summarizes recent findings from 2 landmark randomized clinical trials in the US--the Women's Health Initiative (WHI) and the Heart and Estrogen/progestin Replacement Study
(HERS)--on the role of clinical characteristics, serum/plasma biomarkers, gene markers, and gene- environment interactions in helping to identify good vs poor candidates for HT use with respect to cardiovascular disease (CVD) outcomes.
Results from the Heart and Estrogen-Progestin Replacement Study
(HERS) (JAMA, August 1998), and an even larger study known as the Women's Health Initiative (WHI), published in the July 2002 issue of JAMA led to a rapid decline in the use of estrogen by postmenopausal women due to the potential for increased risk of heart disease.
Taipei, June 2, 2011 (CENS)--Consumer behaviors in TV viewing are changing due to alternate means for watching TV, according to DisplaySearch's latest Global TV Replacement Study
(4,5) When results from the Women's Health Initiative (WHI) and the Heart and Estrogen/progestin Replacement Study
(HERS) provided no evidence for heart disease protection--in fact, even suggesting an increased risk (6-8)--dramatic decreases in HRT use ensued.
(i) DOTG Replacement Study
A: Replacing 4 phr DOTG with 2 phr ACT 55 with 1.2 phr HMDC or 1.85 phr HMDA Cure properties (figures 3 and 4): The HDMA compounds had rheographs similar to the HMDC compounds both at 177[degrees]C and 188[degrees]C.
The Heart and Estrogen/progestin Replacement Study
(HERS) Research Group (I and later II) studies in women who had known preexisting cardiovascular disease initially raised questions about the increase in heart attacks in the first year of hormone therapy use, but it was the publication of the WHI few years later that raised the alarm.
"Although it is commonly understood that postmenopausal women, particularly those with early menopause, have an increased risk of developing coronary artery disease and it was thought that hormone replacement therapy (HRT) would help to remedy this, some well-known clinical investigations, such as the Heart and Estrogen/progestin Replacement Study
(HERS), were unable to demonstrate an improved outcome in postmenopausal women using HRT," said Dr.
The first clinical trial to address the connection between HT hormone use and heart health was the Heart and Estrogen/ Progestin Replacement Study
(HERS), which looked at whether the estrogen/progestin combination Prempro would reduce second heart attacks or cardiac death in women with established coronary artery disease.