Relative TL is expressed as the mean [+ or -] SEM of triplicate samples at the PD upon acrolein-induced senescence (30 PD), the equivalent PD (30 PD) in control cells, and replicative senescence
(46 PD) in control cells.
So replicative senescence
apparently has been retained through evolution as a defense against cancer.
But doubts about the role of telomeres in human replicative senescence
were laid to rest by a report in the journal Science in January 1998.
Furthermore, SIRT6 rescues the decline of base excision repair and homologous recombination repair during replicative senescence
in primary human fibroblast strains [117, 118].
A stochastic step model of replicative senescence
explains ROS production rate in ageing cell populations," PLoS ONE, vol.
Interestingly, the activities of AK and CK significantly decreased during replicative senescence
of myoblasts from passage 2 to passage 6 in both young and older subjects.
of RPE cells was induced by repeatedly passaging cells from the fourth passage to the tenth.
Telomeres shorten with each cell division eventually leading to replicative senescence
, a process thought to be associated with age-related decline in immune function.