reproductive toxicity


Also found in: Medical.

reproductive toxicity

[‚rē·prə‚dək·tiv täk′sis·əd·ē]
(medicine)
Adverse effects on the male and/or female reproductive systems caused by exposure to a toxic chemical. It may be expressed as alterations in sexual behavior, decreases in fertility, or fetal loss during pregnancy. Developmental toxicity may also be included.
References in periodicals archive ?
Associated hazards include: acute toxicity (acute lethality at high concentrations only), blood toxicity, immunotoxicity, cardiovascular toxicity, liver toxicity, kidney toxicity, reproductive toxicity, developmental toxicity, and neurotoxicity.
FA has genetic, mutagenic, carcinogenic and certain reproductive toxicity.
The second workshop was on "New test strategies for developmental and reproductive toxicity (DART)", which was held in May 2017.
The OECD reference guideline for reproductive and developmental toxicity, OECD TG 443 (Extended One-Generation Reproductive Toxicity Study), provides an evaluation of reproductive and developmental effects that may occur in offspring as a result of pre-and post-natal chemical exposure as well as systemic toxicity in pregnant and lactating females (OECD 2011).
Additional testing on food-grade titanium dioxide an extended 90-day study or a multi-generation or extended one-generation reproductive toxicity study according to current OECD guidelines would help to clarify possible reproductive effects and provide more comprehensive data for deriving an ADI.
While they lacked definitive information on the toxicity of the majority of the chemicals, the team members analyzed 240 substances and concluded that 157 of them--chemicals such as arsenic, benzene, cadmium, lead, formaldehyde, chlorine, and mercury--are associated with either developmental or reproductive toxicity.
Also Chrysin (CR), which is one of a flavonoid that naturally exists in propolis can mitigated the side effects of acute Paracetamol (PRC) reproductive toxicity in male which caused decreased the sperm motility, and increased dead sperm rate, abnormal sperm cell rate [51].
Some are known to cause reproductive toxicity at high levels of exposure but the link between low-level exposure and BBP had not yet been thoroughly explored.
Parabens, which are commonly used as a preservative in cosmetics, among other products, mimic estrogen and may cause endocrine disruption and reproductive toxicity.
Ait HN, Slimani M, Merad BB, Zaoiu C (2009) Reproductive toxicity of lead acetate in adult male rats.
who reported that lead induced oxidative stress and reproductive toxicity in male rats Alterations in antioxidant homeostasis resulting alkoxyl radicals which are generated during the conversion of lipid hydro peroxides that fuel the per oxidative chain reaction thereby preventing this damaging process from propagating through plasma membrane (Brigelius-FlohACopyright 2009 and Nadia et al.
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