The intermediate state, which is mapped to G1 and is exited by cells at random, may be associated with the restriction point (RP) of cell cycle ([1, 2, 28] and references therein) and has been suggested to provide a time for cell fate to be determined, that is, whether a cell will pass its RP to divide in its current state or will become committed, upon passing its RP, to change its state so as to make itself or its progeny different, up to the loss of the ability to divide, such as upon a terminal differentiation [1, 2].
EMG has been suggested to be relevant to possible transcriptional mechanisms of the events that are associated with the restriction point of the cell cycle and can determine cell fate [2,11].
The importance of such discrimination follows from the suggestion that the rate of cell differentiation depends on the mean probabilistic rather than deterministic part duration, the former being associated with the restriction point of the cell cycle and suggested to provide cells with time for making a decision, by random choice, whether to continue proliferation or to become committed to withdrawal from the cell cycle .
"The compound we identified forces the catastrophic failure of the normal virus amplification cycle and illustrates a new drug-accessible restriction point
for poxviruses in general," said John Connor, PhD, assistant professor of microbiology at BUSM.