His investigations showed anemia with reticulocytopenia
. He received multiple packed red blood cell (PRBC) transfusions but had a poor increment in his hemoglobin level.
Pure red cell aplasia is characterised by an isolated, often severe anaemia with a marked reticulocytopenia
. It may be congenital (Diamond Blackfan syndrome) or acquired (including viral infections, lymphoproliferative disorders, autoimmune disorders or drugs).
Extreme elevations in LDH in such clinical scenarios along with inappropriate reticulocytopenia
may be more suggestive of underlying [B.sub.12] deficiency.
Haemolytic crisis may be distinguished from aplastic crisis by the finding of a reticulocytosis as opposed to a reticulocytopenia
. Rarely, a hyperhaemolysis syndrome may be triggered by a red cell transfusion.
Diamond-Blackfan anemia (DBA) is a rare congenital hypoplastic anemia characterized by severe normochromic-macrocytic anemia, reticulocytopenia
, a decrease in the number or absence of bone marrow erythroid precursor cells, and normal megakaryocytic and granulocytic differentiation (1-4).
A study from Denmark reported a case of severe anaemia caused by B19 infection in a patient with autoimmune haemolytic anaemia and a B-cell NHL on detection sharply increased B19 viral load, reticulocytopenia
and shortened erythrocyte life-span which are suggestive of a primary parvovirus infection (12).
has been observed in numerous clinical studies of malarial anaemia.
(8) Riboflavin deficiency can cause a normochromic, normocytic anemia and reticulocytopenia
that responds to supplementation.
First described by Kaznelson in 1922 (Krantz, 1974), PRCA has a gradual onset, manifesting as a normochromic, normocytic anemia and reticulocytopenia
with normal white blood cells and platelet count.
Diamond-Blackfan Syndrome, a pure erythrocyte aplasia, presents before the sixth month of life and is notable for anemia, reticulocytopenia
, and decreased erythroid precursors.
Myelosuppression, one of the more common adverse reactions, is thought to be related to an inhibition of ferrochetalase by the drug and leads to anemia, reticulocytopenia
, leukopenia, and thrombocytopenia.