Results indicated higher phagocytic index of treated groups (at dose rate of 100 and 200 mg/kg body weight), which may be due to reticuloendothelial system
stimulation (Neha and Mishra, 2011; Hajra et al., 2012).
As the diameter is smaller than 50 nm, the MPEG-PEI-SPIONs can avoid the phagocytosis of reticuloendothelial system
(RES) and are designed to have a much longer blood half-life and could rapidly circulate almost the whole body.
(8) In addition, IL-1 and TNF-[alpha] induce ferritin transcription, which increases iron storage in the reticuloendothelial system
. The combined effect results in reduced iron availability for erythropoiesis, creating a "functional iron deficiency." (9)
They might accumulate within macrophage phagosomes, nuclei, or in the reticuloendothelial system
or extracellular matrix of the bone, or they may reach the blood stream.
The resultant protamine-heparin complex is rapidly cleared by the reticuloendothelial system
. Protamine is routinely administered postoperatively to reverse the high concentrations of heparin required for patients undergoing cardiac surgery.
It also should not be forgotten that in HH, serum iron levels and the transferrin saturation rate can be within normal limits in cases with an excessive accumulation of iron in reticuloendothelial system
organs and higher ferritin levels.
Leprosy is a systemic disease involving skin, nerves and the reticuloendothelial system
, the liver being the commonest internal organ affected.
The micelle was recognized by reticuloendothelial system
(RES), which is self-defense system of living organisms, and its undesired uptake at liver and spleen was high.
The amphiphilic block copolymer of PCL modified by polyethylene glycol (PEG) could enhance the hydrophilicity of PCL, prevent protein adsorption, evade the recognition and phagocytosis of the reticuloendothelial system
, and easily go through physiological barrier, which has become currently the focus of the nanopharmaceutical research [3-5].
Further,OSE did not show any histological changes in spleen and liver indicating no effect on reticuloendothelial system
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by destruction of circulating antibody bound platelets by reticuloendothelial system
, particularly in the spleen9.
The first has relatively low transferrin saturation with deposition primarily in the reticuloendothelial system
. The second resembles the traditional HFE phenotype targeting the hepatocyte for initial deposition.