KEY WORDS: AHR, cleft, mesenchyme, mouse, nasal epithelium, RAR, retinaldehyde
dehydrogenase (RALDH), teratogenesis, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
One factor reducing the production of ATRA could be limiting amounts of the enzymes involved in the conversion of retinol to retinaldehyde
(ROLDH) and retinaldehyde
to ATRA (RALDH) (Figure 1).
Alcohol dehydrogenase 1 (ADH) is the primary enzyme that oxidizes retinol to retinaldehyde
, and retinaldehyde
inhibits adipocyte differentiation .
In splenic dendritic cells of zymosan- (TLR2 and dectin-1 agonist) treated mice, TLR2 stimulation mediates the inductions of retinaldehyde
dehydrogenase type 2 (Raldh2) and IL-10 expression and stimulates [Foxp3.sup.+] [T.sub.reg] cells induction, suggesting a generally high propensity for tolerance induction after TLR2 signaling .
Molotkov, "Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde
followed by tissue-specific metabolism to retinoic acid," Chemico-Biological Interactions, vol.
Formulas she finds her sensitive clients tolerate well include La Roche Posay Redermic R, PS29.50, Exuviance Super Retinol, PS55, or Avene Physiolift Night Balm, PS26 which contains the milder retinaldehyde
Researchers at the Hebrew University in Israel have found that shutting down a molecule needed to produce retinoic acid, known as retinaldehyde
dehydrogenase (RALDH2), increases sensitivity of developing embryos to low doses of alcohol.
These include retinol, retinaldehyde
, and retinyl esters.
NM_000379.3), aldehyde oxidase (AOX1; EC18.104.22.168; probably identical to retinaldehyde
oxidase, EC22.214.171.124, NCBI geneID: 316, GenBank accession no.
Vitamin A (retinol) is sequentially metabolized to retinaldehyde
, retinoic acid for its functions in animals (Hofman & Eichele 1994, Saari 1994).
"The product features Retinaldehyde
, a seldom-used retinoid with all the efficacy without the side effects often encountered by sensitive patients.The retinaldehyde
molecule lies closer to retinoic acid than other compounds on the retinoid biosynthesis pathway and thus is thought to provide rejuvenating efficacy without inducing as much irritation.
Many previous studies have shown that alcohol dehydrogenase 1 (ADH1) is a major enzyme in achieving the oxidation from retinol to retinaldehyde
in mouse experiments .