Chapters include experiments and general, theoretical, and mechanistic background and explanations, with special emphasis on retrosynthetic analysis
and alternative approaches of synthesis for a given molecule.
The business, founded in 1996, specialises in the computer-aided retrosynthetic analysis
segment, with its ARChem Route Designer system helping chemists design viable synthetic routes for target molecules.
In fact, one approach to organic synthesis known as retrosynthetic analysis
, or "the disconnection approach," is also useful as a strategy for selecting the perfect cleaning process.
The focus of most chapters is mechanistic and stereochemical, with the development of synthetic approaches in forward strategy and generality rather than retrosynthetic analysis
, though the latter is not totally ignored.
Rather than taking a trial-and-error approach based largely on intuition, he and his co-workers developed a system of logical principles -- called retrosynthetic analysis
-- to help in the rational planning of chemical syntheses.
Approaches to synthesis have developed from early bases in analogy, association, and intuition to case study and retrosynthetic analysis
, and molecules under study have become increasingly complex.