reverse mutation


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reverse mutation

[ri′vərs myü′tā·shən]
(genetics)
A mutation in a mutant allele which makes it capable of producing the nonmutant phenotype; may actually restore the original deoxyribonucleic acid sequence of the gene or produce a new one which has a similar effect. Also known as back mutation.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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The Salmonella typhimurium histidine (his) reverse mutation test is a microbial assay which measures his [right arrow] [his.sup.+] reversion induced by chemicals which cause base changes or frameshift mutations in the genome of this organism (Ames et al., 1973, 1975).
Stanley Plotkin's thoughtful overview of the 11 disease-specific chapters annotates new vaccine technologies as well as current issues of debate, such as replacing the live oral polio vaccine worldwide with injectable, inactivated polio vaccine once the eradication program breaks the chain of wild-virus circulation, to avoid reverse mutations and resulting vaccine-associated paralysis.