riboflavin


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.

riboflavin:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
..... Click the link for more information.
; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
..... Click the link for more information.
.

Riboflavin

 

(also lactoflavin and Vitamin B2), an important and biologically active substance that is a derivative of the heterocyclic compound isoalloxazine attached to ribitol, a multi-atomic alcohol.

Riboflavin is widely distributed in the cells of microorganisms, plants, and animals, although animals are unable to bio-synthesize riboflavin and must obtain it with food. The biological role of riboflavin is determined by the presence of its derivatives—flavin mononucleotide (FMN) and flavin-adenine dinucleotide (FAD)—in a series of oxidation and reducing enzymes (flavoproteins) during electron transfer reactions and the metabolism of amino acids and other vitamins.

In man, many diseases are accompanied by disorders of the metabolism of riboflavin. A deficiency of riboflavin results in skin lesions and vision disorders, while an acute insufficiency leads to the development of a comatose state. Riboflavin is present in most food products, including brewer’s yeast, egg yolk, beef liver, and milk products. It is also synthesized by intestinal bacteria.

The structure of riboflavin was independently established in 1935 through chemical synthesis both by R. Kuhn and P. Karrer. Riboflavin is used in medicine as a vitamin preparation.

REFERENCE

Vitaminy. Moscow, 1974. Chapter 8.

riboflavin

[′rī·bə‚flā·vən]
(biochemistry)
C17H20N4O6 A water-soluble, yellow orange fluorescent pigment that is essential to human nutrition as a component of the coenzymes flavin mononucleotide and flavin adenine dinucleotide. Also known as lactoflavin; vitamin B2; vitamin G.

riboflavin

, riboflavine
a yellow water-soluble vitamin of the B complex that occurs in green vegetables, germinating seeds, and in milk, fish, egg yolk, liver, and kidney. It is essential for the carbohydrate metabolism of cells. It is used as a permitted food colour, yellow or orange-yellow (E101). Formula: C17H20N4O6
References in periodicals archive ?
Designing an appropriate fermentation medium is of crucial importance to improve the riboflavin concentration, yield, volumetric production, and the ease of downstream product separation (16).
Lee et al., "Structural response of human corneal and scleral tissues to collagen cross-linking treatment with riboflavin and ultraviolet A light," Lasers in Medical Science, vol.
A central 7 mm round corneal deepithelialization for efficient penetration of riboflavin through exposed corneal stroma was performed with the help of sterile blunt spatula.
"Correlating rheological properties and printability of collagen bioinks the effects of riboflavin photocrosslinking and pH," Biofabrication, Volume 9, Number 3, online 5 July 2017, DOI: 10.1088/1758-5090/aa780f
Riboflavin is able to pass through the lipid cellular membrane and be incorporated into nucleic acid chains.
Chronic migraine patients were likelier to be deficient in riboflavin and CoQ10 than subjects with sporadic migraines.
Hagler's study drew from a database that included patients with migraines who, according to Headache Center practice, had baseline blood levels checked for vitamin D, riboflavin, coenzyme Q10 and folate, all of which were implicated in migraines, to some degree, by previous and sometimes conflicting studies.
The lactobacilli (Thakur et al., 2015b) used in this work were previously described putative riboflavin producing Lactobacillus strains using spectrophotometric assay, polymerase chain reaction and microbiological assay method and high performance liquid chromatography (Thakur and Tomar, 2015c).
Late-onset MADD patient with ETFDH mutation shows a dramatic response to riboflavin, which is known as riboflavin-responsive MADD (RR-MADD), and riboflavin is recommended for treating this disorder since the 1980s.