rifampin

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rifampin

(rĭfăm`pĭn), antibioticantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 used in the treatment of tuberculosistuberculosis
(TB), contagious, wasting disease caused by any of several mycobacteria. The most common form of the disease is tuberculosis of the lungs (pulmonary consumption, or phthisis), but the intestines, bones and joints, the skin, and the genitourinary, lymphatic, and
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. It is also used to eliminate the meningococcus microorganism from carriers and to treat leprosyleprosy
or Hansen's disease
, chronic, mildly infectious malady capable of producing, when untreated, various deformities and disfigurements. It is caused by the rod-shaped bacterium Mycobacterium leprae, first described by G.
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, or Hansen's disease. Rifampin, or rifampicin as it was formerly called, acts by inhibiting protein synthesis in sensitive cells. It is a toxic drug whose side effects include flulike symptoms. Because resistant microorganisms emerge during treatment, rifampin is used along with other drugs, e.g., with isoniazidisoniazid
, drug used to treat tuberculosis. Also known as isonicotinic acid hydrazide, isoniazid is the most effective antituberculosis drug currently available. The drug inhibits or kills the tubercle bacilli that cause the disease.
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 and ethambutol for tuberculosis treatment and with dapsone and clofazimine in the treatment of leprosy.