saccharin


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Related to saccharin: aspartame

saccharin

(săk`ərĭn), C7H5NSO3, white, crystalline, aromatic compound. It was discovered accidentally by I. Remsen and C. Fahlberg in 1879. Pure saccharin tastes several hundred times as sweet as sugar. It is not readily soluble in water, but its sodium salt, which is sold commercially, dissolves readily. Saccharin has no nutritional value and is excreted unchanged by the body. It is used as a sweetener by persons who must limit their consumption of sugar. Despite the fact that saccharin causes cancer in laboratory rats, its ban was rescinded after a public outcry. In 1984 the World Health Organization suggested an intake limit of 2.5 mg/day per kg bodyweight. Other nonnutritive artificial sweetenerssweetener, artificial,
substance used as a low-calorie sugar substitute. Saccharin, cyclamates, and aspartame have been the most commonly used artificial sweeteners. Saccharin, a coal-tar derivative three hundred times as sweet as sugar, was discovered in 1879.
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 include sodium cyclamatecyclamate
, any member of a group of salts of cyclamic acid (cyclohexanesulfamic acid). The sodium and calcium salts were commonly used as artificial sweeteners until 1969, when their use was banned by the U.S.
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 and aspartame.

Saccharin

 

(also o-sulfobenzoic imide), a colorless crystalline substance with the structural formula

Saccharin is poorly soluble in water (1:250) and alcohol (1:40) and has a melting point of 228°–229°C. It is sweet but has a bitter aftertaste. The crystal hydrate of the sodium salt of saccharin, known as Crystallose, has a higher solubility in water (1:1.5).

Saccharin is obtained commercially by the oxidation of o-toluenesulfonamide. With a sweetness 400–500 times that of sugar, saccharin was formerly used in great quantities as a sugar substitute. It is not assimilated by the body but rather is excreted in the urine. Saccharin is used as a sweetener for certain items, such as toothpaste, and as an additive in electroplating technology.

saccharin

[′sak·ə·rən]
(organic chemistry)
C6H4COSO2NH A sweet-tasting, white powder, soluble in acetates, benzene, and alcohol; slightly soluble in water and ether; melts at 228°C; used as a sugar substitute for syrups, and in medicines, foods, and beverages. Also known as benzosulfimide; gluside.

saccharin

a very sweet white crystalline slightly soluble powder used as a nonfattening sweetener. Formula: C7H5NO3S
References in periodicals archive ?
The Israeli group found that mice fed on three artificial sweeteners - saccharin, aspartame and sucralose - developed high blood sugar levels.
Compared with nondrinkers, diet soda consumers "demonstrated more widespread activation to both saccharin and sucrose in reward-processing brain regions," the scientists say.
Bait was prepared (w/w) by mixing cracked groundnut and maize grains, saccharin (Saccharin soluble, Choheung Chemical Ind.
1% (weight/volume) saccharin solution (CS) either 0, 90, or 180 min prior to a 1% body weight intraperitoneal injection of .
Also, their mean saccharin time was shorter (but not significantly so), and their mean nasal airway resistance value during both exhaling and inhaling was substantially (but not significantly) less (figure 1).
Since the 1980s, saccharin has been included in EPA's lists of hazardous wastes, hazardous constituents, and hazardous substances because it was identified as a potential human carcinogen, EPA spokeswoman Latisha Petteway explained.
Evaluation of the dose response and in utero exposure to saccharin in the rat.
While it's reasonable to question natural ingredients as well, I won't use artificial colors and sweeteners, saccharin or preservatives if I have an alternative," he says.
Removal from the list could prompt Congress to lift the requirement for warning labels that say saccharin "has been determined to cause cancer in laboratory animals" on products containing the sweetener.
31, when a National Toxicology Program panel voted to advise keeping saccharin on its list of suspected cancer-causing agents.
The diets were: high in sucrose with no artificial sweeteners; low in sucrose and contained aspartame as the sweetener; and low in sucrose contained saccharin as the sweetener.
Like all Little Remedies[R] products, Little Fevers[R] contains no artificial flavors or colors, no alcohol, saccharin or gluten, offering infants and young children everything they need and nothing they don't.