In order to allocate potential effects to the different constituents of WB, fractions of the extract with different compositions of salicyl alcohol derivative and polyphenols were also investigated.
The FRs were characterized by a high content of flavone and chalcone glycosides (FR-B), flavonoid glycosides and salicyl alcohol derivatives (FR-C), salicin and related salicyl alcohol derivatives (FR-D) and proanthocyanidines (FR-E).
Thus WB (30 mg/kg), its ethanolic fraction rich in salicyl alcohol derivatives (FR-D) (30 mg/kg) and imipramine, by being effective in the FST, modulated known and new targets relevant for neuro- and immunofunctions in rats.
2005; Fiebich and Chrubasik 2004) and that not only salicyl alcohol derivatives, but also the polyphenols of WB contribute to this modulation (Khayyal et al.
The salicin and salicyl alcohol content was determined according Ph.
Table 1 shows a characterization of the WB and its different fractions with regard to the content of different polyphenols and salicyl alcohol derivatives.
They include: glucosides, such as salicin, populin, tremuloidin, salireposide, and grandidentatin; acids such as benzoic and p-hydroxybenzoic; and phenols, such as salicyl alcohol
As this process is also mentionable in vivo for all compounds exhibiting a cyclohexenon carboxylic acid moiety, like the salicyl alcohol derivatives salicortin, 2'-acetylsalicortin and tremulacin (Poblecka-Olech et al.
As there is no further report on the isolation and production of flavonoids associated to orthohydroxybenzyl moiety (typical for salicyl alcohol derivatives), and P.