salicylate


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Related to salicylate: salicylate poisoning, methyl salicylate, benzyl salicylate, Salicylate sensitivity

salicylate

(səlĭs`əlāt'), any of a group of analgesicsanalgesic
, any of a diverse group of drugs used to relieve pain. Analgesic drugs include the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, acetaminophen, narcotic drugs such as morphine, and synthetic drugs with morphinelike action such as meperidine
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, or painkilling drugs, that are derivatives of salicylic acid. The best known is acetylsalicylic acid, or aspirinaspirin,
acetyl derivative of salicylic acid (see salicylate) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic fever and
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. Now often made synthetically, they were originally derived from salicin, the active ingredient in willow bark, used for centuries in the treatment of pain and fever. Salicylates also occur naturally in many plants used as foods (e.g., strawberries, almonds, tomatoes). Methyl salicylate is the main component of wintergreen, sweet birch, gautheria, and betula oils; the compound is used in rubbing linimentsliniment,
liquid preparation rubbed on skin, used to relieve muscular aches and pains. It contains some substance that when rubbed over the affected part causes mild irritation and often brings more blood to the painful part.
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 to soothe muscular aches and as a flavoring. Sodium salicylate, traditionally used in the treatment of arthritis, is also used in dyes and as a nonedible preservative.

In general, salicylates, especially aspirin, are used medically to reduce fever and inflammation and to relieve headache, menstrual pain, and pain in nerves, muscles, and joints. Because of the effects of salicylates on blood platelets and clotting, aspirin is often prescribed prophylactically for those at risk of stroke or heart attack. Salicylates are useful, relatively safe drugs, but normal doses can cause gastrointestinal disturbances in sensitive patients and large doses can be toxic or fatal, especially to children.

salicylate

[sə′lis·ə‚lāt]
(organic chemistry)
A salt of salicylic acid with the formula C6H4(OH)COOM, where M is a monovalent metal; for example, NaC7H5O3, sodium salicylate.
References in periodicals archive ?
Most of the second- and third-degree burns were associated with products that contain menthol as the single active ingredient and with products that contain a combination of menthol (concentration greater than 3%) and methyl salicylate (concentration greater than 10%).
Experiments showed that salicylate did not impact levels of AMP or ADP.
Aspirin is rapidly broken down inside the body into salicylate, so to investigate aspirin's unexpected side-effects Grahame Hardie at the University of Dundee, UK, applied salicylate to cultured human cells derived from the kidney.
We show that salicylate increases fat burning and reduces liver fat in obese mice and that this does not occur in genetically modified mice lacking the beta1 subunit of AMPK," he said.
To investigate aspirin's unexpected side-effects, Grahame Hardie at the University of Dundee, UK applied salicylate to cultured human cells derived from the kidney.
The addition of the volatile compounds methyl salicylate and [beta]-myrcene did not increase captures.
A qualitative assessment of the salicylate content of the medicine indicated a 2+ level of salicylate.
Unlike aspirin, however, sodium salicylate neither effectively inhibits the COX enzymes nor blocks prostaglandin synthesis.
Researchers looked at 16 studies involving nearly 1,300 patients using creams containing salicylate - a close drug relative of aspirin.
As of April 16 this year, three suspected serious adverse drug reactions (ADR) reports were received by the MHRA in association with the use of oral gels containing choline salicylate, including Bonjela.
As of April 16 this year, three suspected serious adverse drug reactions reports were received by the MHRA in association with the use of oral gels containing choline salicylate, including Bonjela.
Voluntary hyperventilation, respiratory stimulants such as salicylates, cerebral disturbance such as trauma, infection and tumors, liver failure, septicemia due to gram negative organisms, and primary hyper- ventilation syndrome.