salicylate


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salicylate

(səlĭs`əlāt'), any of a group of analgesicsanalgesic
, any of a diverse group of drugs used to relieve pain. Analgesic drugs include the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, acetaminophen, narcotic drugs such as morphine, and synthetic drugs with morphinelike action such as meperidine
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, or painkilling drugs, that are derivatives of salicylic acid. The best known is acetylsalicylic acid, or aspirinaspirin,
acetyl derivative of salicylic acid (see salicylate) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic fever and
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. Now often made synthetically, they were originally derived from salicin, the active ingredient in willow bark, used for centuries in the treatment of pain and fever. Salicylates also occur naturally in many plants used as foods (e.g., strawberries, almonds, tomatoes). Methyl salicylate is the main component of wintergreen, sweet birch, gautheria, and betula oils; the compound is used in rubbing linimentsliniment,
liquid preparation rubbed on skin, used to relieve muscular aches and pains. It contains some substance that when rubbed over the affected part causes mild irritation and often brings more blood to the painful part.
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 to soothe muscular aches and as a flavoring. Sodium salicylate, traditionally used in the treatment of arthritis, is also used in dyes and as a nonedible preservative.

In general, salicylates, especially aspirin, are used medically to reduce fever and inflammation and to relieve headache, menstrual pain, and pain in nerves, muscles, and joints. Because of the effects of salicylates on blood platelets and clotting, aspirin is often prescribed prophylactically for those at risk of stroke or heart attack. Salicylates are useful, relatively safe drugs, but normal doses can cause gastrointestinal disturbances in sensitive patients and large doses can be toxic or fatal, especially to children.

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salicylate

[sə′lis·ə‚lāt]
(organic chemistry)
A salt of salicylic acid with the formula C6H4(OH)COOM, where M is a monovalent metal; for example, NaC7H5O3, sodium salicylate.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Effect of salicylate on neuronal firing rate of hippocampal CA1 area
Products containing salicylate include but are not limited to aspirin and PeptoBismol.
Effect sizes (A values) varied substantially; they were relatively high for eucalyptol/benzyl acetate and eucalyptol/eugenol comparisons, and low for all comparisons involving methyl salicylate.
Analgesics, including aspirin, were the most common etiology of all drug poisonings in the USA, with salicylate poisoning leading to a fatal outcome in 34 patients out of 2113 deaths reported in 2013 [54].
Figure 1 exhibits the XRD patterns for salicylic acid, ZHN, and LHS (salicylate) while Figure 2 displays the X-ray diffraction patterns for palmitic acid, Zn/Al palmitate, ZHN, and LHS (palmitate).
This mixed respiratory alkalosis and metabolic acidosis were suggestive for salicylate poisoning, and ventilator settings were adjusted to increase the respiratory rate (increased to 25, as compared to the patient's initial 20 breaths/minute) and tidal volume (increased to 620 mL, approximately 10 mL/kg of total body weight, as ideal body weight was unknown), which were the maximal tolerated settings.
Recently, we have discovered a simple one-step process for ultra-fast electropolymerization of aniline on mild steel in an aqueous salicylate solution.
Animals were randomly assigned into two groups (even numbers GDD and odd numbers GSM): group subjected to the application of aerosol containing diclofenac diethylammonium (GDD: 9 animals for the cutaneous tissue, and 9 animals for the subcutaneous), and group subjected to the aerosol with methyl salicylate (GSM: 9 animals for the cutaneous tissue, and 9 animals for the subcutaneous).
The phenyl salicylate presents a very low absorption in the solar ultraviolet region.
One of the most reliable methods of inducing transient tinnitus involves administering a large dose of sodium salicylate (SS) [1, 2], the active ingredient in aspirin.
In this study, allelopathic induction in rhizosphere after exogenous application of signaling compounds methyl jasmonate and methyl salicylate was evaluated.
X-ray diffraction studies of the various solid aerosols pools (residential, industrial, transportational, commercial and mix pools) showed that non- clay organic compounds such as GB-Naphthylbismuth dioxide, Sodium hippurate, Sodium-GA-naphthylamine-4- sulfonate tetrahydrate, Potassium phenoxide, Bismuth salicylate, Cadmium salicylate hydrate, Barium phenolsulfonate are contained in most of the samples in almost comparable amounts.The results of Solid aerosols collected from various pools show that the sources of GB-Naphthylbismuth dioxide, Sodium hippurate, Sodium-GA-naphthylamine-4-sulfonate tetrahydrate, Potassium phenoxide, Bismuth salicylate, Cadmium salicylate hydrate, Barium phenolsulfonate in the Solid aerosols are both local and remote.