salicylate


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salicylate

(səlĭs`əlāt'), any of a group of analgesicsanalgesic
, any of a diverse group of drugs used to relieve pain. Analgesic drugs include the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, acetaminophen, narcotic drugs such as morphine, and synthetic drugs with morphinelike action such as meperidine
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, or painkilling drugs, that are derivatives of salicylic acid. The best known is acetylsalicylic acid, or aspirinaspirin,
acetyl derivative of salicylic acid (see salicylate) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic fever and
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. Now often made synthetically, they were originally derived from salicin, the active ingredient in willow bark, used for centuries in the treatment of pain and fever. Salicylates also occur naturally in many plants used as foods (e.g., strawberries, almonds, tomatoes). Methyl salicylate is the main component of wintergreen, sweet birch, gautheria, and betula oils; the compound is used in rubbing linimentsliniment,
liquid preparation rubbed on skin, used to relieve muscular aches and pains. It contains some substance that when rubbed over the affected part causes mild irritation and often brings more blood to the painful part.
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 to soothe muscular aches and as a flavoring. Sodium salicylate, traditionally used in the treatment of arthritis, is also used in dyes and as a nonedible preservative.

In general, salicylates, especially aspirin, are used medically to reduce fever and inflammation and to relieve headache, menstrual pain, and pain in nerves, muscles, and joints. Because of the effects of salicylates on blood platelets and clotting, aspirin is often prescribed prophylactically for those at risk of stroke or heart attack. Salicylates are useful, relatively safe drugs, but normal doses can cause gastrointestinal disturbances in sensitive patients and large doses can be toxic or fatal, especially to children.

salicylate

[sə′lis·ə‚lāt]
(organic chemistry)
A salt of salicylic acid with the formula C6H4(OH)COOM, where M is a monovalent metal; for example, NaC7H5O3, sodium salicylate.
References in periodicals archive ?
Products containing salicylate include but are not limited to aspirin and PeptoBismol.
Effect sizes (A values) varied substantially; they were relatively high for eucalyptol/benzyl acetate and eucalyptol/eugenol comparisons, and low for all comparisons involving methyl salicylate.
The ignition delay of lubricant with salicylate detergent is always shorter than lubricant with sulfonate detergent in the whole temperature range
The aqueous sodium salicylate solution was used as the supporting electrolyte to synthesize PAOA copolymer coatings on mild steel.
Excipients: methyl salicylate, menthol, triclosan, propylene glycol, isopropyl alcohol and deodorized mixture of butane and propane-values not specified in the package insert (BIOFENAC, 2006).
Lower fading of yellow dyed and treated with phenyl salicylate and vitamin C combination.
Methyl jasmonate and methyl salicylate are important signaling compounds and have pronounced affect on plant growth and development (Smith et al.
12)% in Pool(4*2), Bismuth salicylate (5) in amounts ranging between (61.
The literature report described a patient who developed full-thickness skin and muscle necrosis and persistent interstitial nephritis after topical application of methyl salicylate and menthol, followed by the use of a heating pad (Cutis 1987;39:442-4).
Clinical data on type II diabetic humans showed that when aspirin or salsalate (a salicylate precursor) were taken, there was a large drop in circulating free fatty acids," says Gregory Steinberg, associate professor in the Department of Medicine at McMaster University and one of the co-authors of the paper.
Exactly why salicylate shows such potential as an anti-cancer treatment remains unclear, but a new study in mice offers clues.
Researchers in Canada, Scotland and Australia have discovered that salicylate, the active ingredient in aspirin, directly increases the activity of the protein AMPK (AMP-activated protein kinase), a key player in regulating cell growth and metabolism.