scaffold protein


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scaffold protein

[′ska‚fōld ‚prōtēn]
(cell and molecular biology)
A protein that assembles interacting signaling proteins into multimolecular signaling complexes.
References in periodicals archive ?
By binding to inhibitory glycine and GABAA receptors, gephyrin acts as a central scaffold protein of inhibitory postsynapses in the mammalian central nervous system.
Still, our experience with affibody-based imaging probes suggests that the composition of the binding site of a scaffold protein may influence off-target interaction of an imaging probe affecting its accumulation in normal tissues and blood clearance rate [19-21].
As a PDZ domain-containing scaffold protein, PDZD7 plays important roles in organizing protein complex.
CUL7 encodes for the CUL7 protein that is a scaffold protein forming part of an E3 ubiquitin ligase enzyme responsible for cytoplasmic protein degradation.
Most of the biological processes in living cells hardly occur without protein interactions mediated by scaffold proteins. PDZK1 (PDZ domain containing 1) is a scaffold protein containing four PDZ protein interaction domains which interacts with a number of membrane transporter proteins, including ion channels and drug transport proteins, affecting their subcellular signaling transduction, membrane localization, and transport activities [10].
Since its discovery as an intracellular protein with similarities to [sz]-subunits of G-proteins, a whole wealth of potential functions for RACK-1 have been described, including its participation as a scaffold protein, [sup][9] activator of protein kinase C [sup][10] and binder and activator of inositol trisphosphate receptors.
According to scientists from OSU and Oregon Health and Science University, finding ways to maintain or increase the effectiveness of this gene - called Grp1-associated scaffold protein, or Grasp - could offer an important new avenue for human cancer therapies.
TRB3 also serves as a scaffold protein and regulates the activation of the three classes of mitogen-activated protein kinases (MAPKs) [10].
Marfan syndrome is caused by mutations in the gene FBN1, which result in reduced production of fibrillin-1, a major scaffold protein important in creating and stabilizing connective tissue.
Marfan syndrome is caused by mutations in the gene FBNl, which result in reduced production of fibrillin-1, a major scaffold protein important in creating and stabilizing connective tissue.
In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold proteins is BBI.
The center has discovered that B cell scaffold protein with ankyrin repeats (BANK), a kind of adapter molecule, inhibits the immune response of the B cell.