scaffold protein


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scaffold protein

[′ska‚fōld ‚prōtēn]
(cell and molecular biology)
A protein that assembles interacting signaling proteins into multimolecular signaling complexes.
References in periodicals archive ?
Since its discovery as an intracellular protein with similarities to [sz]-subunits of G-proteins, a whole wealth of potential functions for RACK-1 have been described, including its participation as a scaffold protein, [sup][9] activator of protein kinase C [sup][10] and binder and activator of inositol trisphosphate receptors.
According to scientists from OSU and Oregon Health and Science University, finding ways to maintain or increase the effectiveness of this gene - called Grp1-associated scaffold protein, or Grasp - could offer an important new avenue for human cancer therapies.
In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein.
The center has discovered that B cell scaffold protein with ankyrin repeats (BANK), a kind of adapter molecule, inhibits the immune response of the B cell.
Barriers and Channels Formed by Tight Junction Proteins I showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system
It is known that many T cell signalling proteins (such as the kinase Lck and the scaffold protein LAT) are not randomly distributed within the plasma membrane thus giving rise to lateral organization which affects signalling efficiency.
The NYU-Poly scientists inserted the unstable exoinulinase (EI) protein into a thermophilic scaffold protein, which is known for its stability and a propensity to protect less stable proteins.
Correlating the organization of exocytosis and endocytosis sites with the location of key proteins such as calcium channels and scaffold proteins will reveal the functional microarchitecture of the presynaptic nerve terminal.