Sclerodermatous lesions after HSCT have a broad clinical spectrum and present therapeutic challenges .
Garcia-Diez, "Sclerodermatous graft-versus-host disease," Archives of Dermatology, vol.
du Vivier et al., "Sclerodermatous graft-versus-host disease: clinical spectrum and therapeutic challenges," British Journal of Dermatology, vol.
The syndrome is characterized by premature ageing with sclerodermatous skin changes, subcutaneous calcification, short stature, prematurely aged facies, premature arteriosclerosis, diabetes mellitus and a predisposition to malignancy.
Clinical features: The cutaneous features of Werner's syndrome include sclerodermatous skin changes, particularly on the face and extremities, and subcutaneous calcification.
We assessed age, sex, pretransplant diagnosis, conditioning regimen, GVHD prophylaxis, and occurrence of acute GVHD (aGVHD), chronic lichenoid and chronic systemic GVHD, and clinical properties of sclerodermatous GVHD.
Leopard skin eruption appeared in 8 (36.4%) of the 19 patients with generalized sclerodermatous changes.
Conclusion: Sclerodermatous GVHD has a late onset and may be quite disabling.
Key words: Allogeneic hematopoietic stem cell transplantation, sclerodermatous graft-versus-host disease
Lichenoid and sclerodermatous changes have been described (2-6).
Nevertheless, few data are available regarding the late sclerodermatous phase of cGVHD.
Urticaria-like skin manifestations were not present in our study and it is rare in SLE patients.26 Though Dubois27 recommended that urticaria in SLE should be carefully evaluated as a clue for systemic disease flare.Erythema multiforme, sclerodermatous
changes, and lichen planus were not seen in this study.