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Related to sclerosis: Systemic sclerosis


1. Pathol a hardening or thickening of organs, tissues, or vessels from chronic inflammation, abnormal growth of fibrous tissue, or degeneration of the myelin sheath of nerve fibres, or (esp on the inner walls of arteries) deposition of fatty plaques
2. the hardening of a plant cell wall or tissue by the deposition of lignin
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



the hardening of an organ or tissue in humans and animals caused by connective-tissue overgrowth. Functionally valuable elements of the parenchyma of a sclerosed organ are destroyed and replaced by mature and sometimes coarse-fibered connective tissue, which often contains deposits of amyloid, hyalin, and lime. New connective tissue is usually formed by the reproduction of fibroblasts (connective-tissue cells) and by the intensified formation of collagen molecules by the fibroblasts.

In cases of sclerosis, parenchymal elements may be destroyed by inflammatory processes that are usually chronic in nature, including tuberculosis, rheumatic fever, and syphilis, and by circulatory disturbances, including passive congestion. Parenchymal elements may also be destroyed by involutional changes, for example, the postpartum sclerosis of the corpus lutea, and by changes associated with age and by metabolic disturbances. Sclerosis may be focal or diffuse. The proliferated connective tissue may become corrugated, resulting in the deformation of the organ, or cirrhosis. During cirrhosis, the hardening and reduction of an organ are accompanied by surface changes, including alternating outpouchings and invaginations, such as in a granular kidney or nodular liver.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


Hardening of a tissue, especially by proliferation of fibrous connective tissue.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The addition of Raynaud's phenomenon and nail fold capillary microscopy and systemic sclerosis selective antibodies as additional minor criteria improve the sensitivity of these criteria.5 This study intended to explore the cutaneous and systemic features of patients of SSc in the East-central part of India.
For information about the National Multiple Sclerosis Society, Greater Illinois Chapter, visit, or
In a recent study, it was found that this receptor present in the microglial cells that increases their anti-inflammatory potential in order to reduce the damage in Multiple Sclerosis and, above all, encourage the body's own repair responses.
The Chi-square test was used to find the association of type of systemic sclerosis and ECG abnormality.
Biogen Japan President and Representative Director Shinichi Torii commented, "Biogen is a leading company in multiple sclerosis, and approximately 40% of multiple sclerosis patients worldwide use Biogen's medicines.
Results: The mean age of study participants was 39.8 +- 8.91 years, 71.8% of them resided in urban areas whereas the mean duration of Multiple Sclerosis in these participants was 9.61 +- 2.0 months.
Multiple sclerosis (MS) is the most common disease of central nervous system (CNS) and research regarding clinical and radiographic features, epidemiology, treatment options, and prognosis of paediatric MS has increased significantly all over the world.1 MS patients may exhibit any neurological symptoms as vision loss, paralysis, numbness and, walking difficulties.
Glial scarring (sclerosis) occurs as the body attempts to repair the neuronal cellular damage (remyelination), and in early stages of the disease this scarring can occur.
Conclusion: Tuberous sclerosis is a rare genetic condition that mainly causes development of hamartomas.
Herein we report a case with docetaxel-induced systemic sclerosis with internal organ involvement masquerading as a congestive heart failure (CHF).