It followed logically that substitution of phenobarbital, a long-acting barbiturate, for secobarbital
, a short-acting one, at a sub-intoxicating dose was a reasonable treatment strategy.
Drug Maximum detection time Alcohol (ethyl) 3 to 10 hours Amphetamines 24 to 48 hours Barbiturates 24 hours (Secobarbital
* A doctor might pilfer several red devils secobarbital
sodium) for a friend.
The inquest was told one of the drugs included Secobarbital
, not normally prescribed to patients in Britain.
Several ultrashort-acting barbiturates are used for anesthetic induction (thiopental, thiamylal, and methohexital), as hypnotics (pentobarbital and secobarbital
), and for seizure control and prophylaxis (phenobarbital).
The requirements for attending/prescribing or consulting a physician to write the prescription for secobarbital
or phenobarbital is clear (see Table 1).
Monitoring saliva concentrations of methaqualone, codeine, secobarbital
, diphenhydramine and diazepam after single oral doses.
The label change affects drugs including Zolpidem, marketed as Ambien/Ambien CR by Sanofi-Aventis; butabarbital, marketed as Butisol Sodium by Medpointe Pharmaceuticals HLC; flurazepam, marketed as Dalmane by Valeant Pharmaceuticals; quazepam, marketed as Doral by Questcor Pharmaceuticals; triazolam, marketed as Halcion by Pharmacia & Upjohn Inc.; eszopiclone, marketed as Lunesta by Sepracor Inc.; estazolam, marketed as Prosom by Abbott; temazepam, marketed as Restoril by Tyco Healthcare Group; ramelteon, marketed as Rozerem by Takeda Pharmaceutical Inc.; secobarbital
, marketed as Seconal by Ranbaxy Pharmaceuticals Inc.; and zaleplon, marketed as Sonata by King Pharmaceuticals Inc.
Thirty-four patients used the prescription drug phenobarbital, two used secobarbital
, and two used Tuinal.
The primary problem is that the drug secobarbital
was used in
Interaction of secobarbital
with warfarin pseudoracemates.
Mental health drugs included: central nervous system stimulants (e.g., methylphenidate, pemoline, provigil); anxiolytic/sedative--hypnotics which includes, benzodiazepines (e.g., diazepam, alprazolam), nonbenzodiazepines (e.g., buspirone), barbiturates (e.g., secobarbital
, amobarbital), and nonbarbiturates (e.g., zolpidem, chloral hydrate, glutethemide); antimanic drugs (i.e., lithium); select anticonvulsants with mood-stabilizing properties (e.g., carbamazepine, clonazepam, lamotrogine, topiramate, valproic acid/valproate); antidepressants; and antipsychotics.