But there's secondary damage
due to the release of excess glutamates, which are responsible for additional functional disability," says Yona Goldshmit, PhD, of TAU's Sackler Faculty of Medicine and the Australian Regenerative Medicine Institute, Monash University.
The blood brain barrier is also disrupted in neurotrauma, leading to secondary damage
. The award is a "fast-track" grant, meaning Phase 1 and Phase 2 proposals are submitted simultaneously for evaluation.
This leads to a decrease in inflammation and subsequent secondary damage
to the brain and spinal cord.
I would like to ask if any Express reader out there is aware of the number of complaints that have been raised, either because of physical damage to vehicles or even secondary damage
caused by bits of road being thrown into the air by vehicles as they drive over the potholes.
After ICH, the hematoma components initiate an inflammatory signaling through the activation of microglia, which culminates on secondary damage
One of the mechanisms of secondary damage
might be a local increase in the inflammatory response and proinflammatory cytokines because these cytokines rise endogenously in the first 2 weeks after noise exposure, which in turn increases inflammatory cell infiltration [8, 11].
Mold that is deemed secondary damage
to an original loss from wind or water may not be covered.
The treatment could potentially limit secondary damage
to the spinal cord in humans after an injury, if administered a few hours after an accident in an emergency room or by paramedics in an ambulance.
As a consequence of the primary damage, a series of cellular factors that affect the nearby tissue are released producing inflammation, which in turn increases neuronal damage and the progressive loss of axons, causing secondary damage
. Right after the primary lesion, an active state of proinflammatory responses accompanied by tissue swelling and the formation of vasogenic edema takes place .
The pathophysiology of BI is composed of two different pathogenetic moments: primary damage due directly to trauma, with mechanical forces applied to the head, and subsequent biochemical events due to a complex cell response that leads to the death of neuronal cells and classified as secondary damage
. Accumulating evidence suggests that the extent of brain injury and the clinical outcome after BI are modulated, to some degree, by genetic variants.
To be more specific, mechanical injury to the spinal cord causes initial damage to neurons and axons, and secondary damage
can be induced by the ensuing inflammatory responses [2, 3], loss of blood supply, and excess release of excitatory neurotransmitters .
These candidate drugs block the events that cause secondary damage
, including inflammation, high levels of free radicals, over-excitation of neurons, and signaling that leads to cell death.