Watery diarrhea, hypokalemia and achlorhydria syndrome which was described by Verner and Morrison (1) in 1958 for the first time (WDHA) is a rare cause of chronic secretory diarrhea
arising from a vasoactive intestinal peptide (VIP) secreting tumor.
In adults, the most common etiologies were secretory diarrhea
(idiopathic, laxative abuse, irritable bowel syndrome, diabetes mellitus, and fecal incontinence), malabsorption (pancreatic disease, noninflammatory short bowel syndrome, postgastrectomy, hyperthyroidism, and cholestasis), microscopic colitis, inflammatory bowel disease, celiac sprue, and radiation colitis.
The nonspecific symptoms most commonly reported are cough, secretory diarrhea
, headache, fatigue, memory impairment, rash, difficulty in concentrating, light sensitivity, burning skin upon water contact, muscle ache, and abdominal pain.
The girl, who suffered from secretory diarrhea
, an unusual disease in which a person cannot obtain any nutrition from food, received a new liver, stomach, duodenum, pancreas, and small intestine.
Using Virginia opossums, University of Missouri scientists Leonard Forte and Ronald Freeman have made several breakthroughs into the cause of secretory diarrhea
, a disease that kills more than 4,000,000 people in developing countries each year.
LT can promote intestinal mucosal cell secretion, resulting in diarrhea and dehydration; ST can increase cGMP production, causing secretory diarrhea