PTEN expression was significantly higher in proliferative and secretory endometrium
than in endometrial hyperplasia with atypia and endometrioid carcinoma.
Genome-wide microarray analysis of long non-coding RNAs in eutopic secretory endometrium
was the second most common pattern observed in this study and was seen in 372 (24.1%) patients.
The excess of estrogen is initially reflected as disordered proliferative endometrium.16 In our study this effect was seen in 17.5% of cases (figure 3) which is second after secretory endometrium
and turns out to be the first among the abnormal morphologies found in infertile women.
is the commonest diagnosis in women of reproductive age group whereas hyperplasia and malignancy are common in premenopausal and postmenopausal age groups.
The problem is common worldwide but the causes may vary from one region to another.2 The aetiology of AUB includes a wide range of disorders that can be secondary to female genital tract pathology, pregnancy and pregnancy-related disorders, and systemic illnesses.3 Spectrum of common pathologies that can be detected histologically in AUB include proliferative endometrium, secretory endometrium
, chronic non- specific endometritis, endometrial hyperplasia without atypia and endometrial hyperplasia with atypia.
Endometrial aspiration revealed secretory endometrium
with neoplastic cells and hysterectomy was done.
The authors analysed Rb2/p130 expression by immunohistochemistry staining in 102 specimens chosen to represent a spectrum of endometrial changes, including proliferative endometrium (n = 18), secretory endometrium
(n = 18), simple or complex hyperplasia without atypia (n = 18), atypical hyperplasia (n = 18), and invasive carcinoma (n = 30).
highly expresses urocortin messenger RNA and peptide: possible role in the decidualization process.
84 (20.58%) had abnormal uterine bleeding with endometrium in proliferative phase, 24 (5.88%) were secretory endometrium
, 10 (2.45%) had endometrial atrophy, 05 (1.22%) showed disordered proliferative endometrium with 7 (1.71%) cases of endometrial hyperplasia and 2 (0.49%) granulomatous endometritis.
The relative ratio and duration of each hormone determine the histologic appearance of the endometrium from proliferative endometrium to secretory endometrium
and finally withdrawal and breakdown.
The predominant pattern was secretory endometrium
in 52 cases (34.6%) followed by proliferative endometrium in 45 cases (30%).