"Sometimes people talk about senescence
as a double-edged sword, that it protects against cancer, and that's a good thing," Graham said.
is interfered with, it could risk the development of cancer.
Our preliminary study may provide a solid basis to identify the complex extracellular protein networks involved in the senescence
doi:10.1001/jama.2018.9562 Scientific Discovery and the Future of Medicine Aging, Cell Senescence
, and Chronic Disease: Emerging Therapeutic Strategies Tamara Tchkonia, PhD; James L.
Effect of SASP on neuronal senescence
will be studied using a set of well-established markers like Telomere Associated DNA damage Foci (TAF), Sen-beta-Gal, p21 and markers of nuclear envelop maintenance.
This is the first study in the literature to assess the senescence
effects of anti-VEGF drugs and to identify that these agents do not seem to have a significant effect on the senescence
of RPE cells in vitro.
was analyzed with the SA-[sz]-Gal staining kit (Sigma), according to the manufacturer's recommendations.
CSE Can Induce Human Bronchial Epithelial Cellular Senescence
. To detect the effect of the CSE on airway epithelial cells, we treated 16HBE cells with increasing concentrations of the CSE for different durations.
Motivated by the fact that MSCs have only a limited lifespan in long-term culture, the main assumption of our model is that oxygen tension can influence the progression of replicative senescence
during MSC aging.
Accordingly, we recently investigated the "senescence
" of endothelial cells (ECs) and the consequent endothelial dysfunction as one of the main trigger involved not only in the onset and progression of CVDs but also of other ARDs like osteoporosis [24, 27], since ECs are components of the stroma of all tissues and organs [28-30].
The aim of the present study was to improve the vase life of cut tuberose by delaying senescence
is defined as the final phase of ontogeny of the organ in which series of irreversible changes are initiated in the plant tissues leading to cellular breakdown and death of the organ.
Keywords: Biostimulants; Zeatin; Grain filling; Leaf senescence
; Seed priming