senescence

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senescence

[si′nes·əns]
(biology)
The study of the biological changes related to aging, with special emphasis on plant, animal, and clinical observations which may apply to humans.
(geology)
The part of the erosion cycle at which the stage of old age begins.
References in periodicals archive ?
Table 5--Farinaceous pulp and senescent degeneration incidence of 'Baigent' apple pretreated with aminoethoxyvinylglycine (AVG) and ethephon, harvested on two dates after four months of cold storage and seven days under room condition.
He said that human clinical trials are still in early stages, but studies with mice have shown that by eliminating senescent cells, mice age better, with a more productive life span.
While clinical trials on human beings are still in nascent stages, it was important to understand the uniqueness of a senescent cell, so that drugs doA not negatively affect non-senescent cells and do not cause any side effects.A
The researchers used a drug called a senolytic--dasatinib plus quercetin, an open-label drug, to clear the senescent cells."
Researchers have known about the problem of senescent cells for some time.
You've suggested that health care could be transformed by senolytic drugs, which eliminate senescent cells.
The elderly often have lots of harmless brain cells that look like the dangerous senescent cells a drug would target, so the molecule would have to be good at telling the two apart.
According to the company, the senescent cell elimination represents one of the most promising targets in a fight against the diseases of aging.
GlcN reduced the proportion of SA-[sz]-Gal-positive cells, a senescence marker, in H[sub]2O[sub]2-induced prematurely senescent RPE cells.
This evidence suggests that a senescent milieu could also reduce the stemness properties [22] or the differentiation capacity [23].
Although the effects of DNMTIs alone or in combination with radiotherapy are well reported, it is not known how the senescent and/or normal stromal cells of the tumor microenvironment influence the response of cancer cells to DNA-demethylating drugs.