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The treatment of disease by means of human or animal serum containing antibodies. Also known as immunotherapy.



the treatment of primarily infectious diseases of humans and animals by the injection of immune serums. The therapeutic effect is based on the phenomenon of passive immunity; microbes (toxins) are rendered harmless with antibodies (antitoxins), which are contained in serums obtained by hyperimmunization of animals, primarily horses. Purified and concentrated serums known as gamma globulins are also used in serotherapy; gamma globulins may be heterologous, meaning they are extracted from the serum of immunized animals, or homologous, meaning they are extracted from the serum of individuals who have been immunized or have had the disease.

Immune serums are used in the treatment of diphtheria (mainly in the initial stage of the disease), botulism, and poisonous snake bites, and gamma globulins are used in the treatment of influenza, anthrax, tetanus, pox, Russian spring-summer encephalitis, leptospirosis, and staphylococcus infections, especially those caused by microbes resistant to antibiotics. In order to prevent possible complications during serotherapy, including anaphylactic shock and serum sickness, serums and heterologous gamma globulins are administered after a preliminary skin test according to a special method.

In veterinary medicine, immune serums, including gamma globulins, are used in the treatment of anthrax, hemorrhagic septicemia in cattle, sheep, and swine, anaerobic lamb dysentery, and swine erysipelas.


References in periodicals archive ?
The variables investigated in clinical evaluations were: local and systemic clinical manifestations, seriousness and evolution of the case, and serotherapy. Demographic and population data furnished by the Brazilian Institute of Geography and Statistics (IBGE) were used to calculate incidence rates.
In HLA-matched or mismatched unrelated donor setting, conditioning regimens will often include serotherapy such as Alemtuzumab (monoclonal anti-CD52 antibody) or thymoglobulin (polyclonal horse or rabbit thymocyte globulin [ATG]) to remove alloreactive T cells in the recipient that can cause acute Graft versus Host Disease (GVHD).
It was found in supernatants from cultured ovarian cancer cells, limiting its potential for serotherapy. A shed antigen, however, might prove valuable as a biomarker to monitor response to treatment and thus fill an unmet clinical need.
Envenomation by Viperidae snakes causes local tissue damages such as edema, hemorrhage, and myonecrosis, which are not well neutralized by conventional antivenom serotherapy [3].
Serotherapy, a popular treatment by the 1930s, involved injecting animal-derived antibodies to a specific strain of bacteria into people.
The Instituto Oswaldo Cruz was created in 1900 as the Federal Serotherapy Institute with the objective of producing serum for bubonic plague.
First experience with serotherapy in treatment of PMWS in Czech Republic.
History of the primordia of snake-bite accident serotherapy. Mem do Instit Butantan.
Ethnic groups from these zones use herbal remedies against this type of accident without the antivenom administration (serotherapy), that is, the therapeutic process accepted at present (Dehesa-Davila, 1986; Hutt and Houghton, 1998).