To assess the effect of the eight sesquiterpene lactones
present in the extract (C[H.
(STL) are a group of bioactive substances consisting of a broad spectrum of sesquiterpenes which have been identified in a number of plant families such as Acanthaceae, Apiaceae, Lauraceae, Magnoliaceae, Rutaceae, and Asteraceae (Saeidnia et al.
Several sesquiterpene lactones
having an [alpha]-methylene-[gamma]-lactone moiety such as parthenolide, eupatoriopicrin, costunolide (Julianti et al.
as drugs with multiple targets in cancer treatment: focus on parthenolide.
Two cytotoxic sesquiterpene lactones
from the leaves of Xanthitan strumarium and their in vitro inhibitory activity on farnesyltransferase.
These features make sesquiterpene lactones
potent molecules for the treatment of human pathogenic protozoa species, including trypanosomatids.
Our results clearly indicated that sesquiterpene lactones
are good candidates for the development of new antimicrobial agents acting not as bactericidal but as antipathogenic agents.
A] receptors mainly through the two sesquiterpene lactones
atractylenolide II and Ill (Fig.
Parthenolide, a sesquiterpene lactone
isolated from many members of the genus Tanacetum, exhibits anti-inflammatory properties and is used clinically for treatment of migraine (Murphy et al.
By and large the activity of the herb might be attributed to the major compound, camphor and to two other major sesquiterpene lactones
, absinthin and artabsin, which are known to occur in the plant (van Wyk and Wink 2004).
The above documents prompted us to investigate anti-tumor-promoting effects of a terpenoid coumarin, diversin (compound 1), together with four new sesquiterpene lactones
, diversolides A, D, F and G (compounds 2-5) (Fig.
are secondary metabolites commonly found in plants from the Asteraceae family that can display a broad array of biological/therapeutical activities (Pickman 1984; Da Costa et al.