sialic acid


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Related to sialic acid: salicylic acid

sialic acid:

see glycoproteinglycoprotein
, organic compound composed of both a protein and a carbohydrate joined together in covalent chemical linkage. These structures occur in many life forms; they are prevalent and important in mammalian tissues.
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Sialic Acid

 

any of the monobasic polyhydroxy amino acids that are derivatives of neuraminic acid. Sialic acids are colorless crystalline solids that dissolve readily in water but are insoluble in nonpolar solvents. They decompose without melting in the temperature range 130°-200°C and are easily decomposed by the action of acids and bases. In nature, as components of glycoproteins and glycolipids, sialic acids are found in, among other places, the cell walls of animals, nerve tissue, and mucous secretions. The biosynthesis of biopolymers containing sialic acids is carried out using the activated form of sialic acids, namely, cytidine monophosphate-sialic acids, which are special sialyltransferase enzymes. Sialic acids determine the antigen and receptor properties of cell surfaces, participating in the interaction of the surfaces with, for example, viruses, toxins, and hormones.

sialic acid

[sī′al·ik ′as·əd]
(biochemistry)
Any of a family of amino sugars, containing nine or more carbon atoms, that are nitrogen- and oxygen-substituted acyl derivatives of neuraminic acid; as components of lipids, polysaccharides, and mucoproteins, they are widely distributed in bacteria and in animal tissues.
References in periodicals archive ?
Boyd, "Host-derived sialic acids are an important nutrient source required for optimal bacterial fitness in vivo," mBio, vol.
sonchifolia on Lung tumour nodule formation, rate of survival and on the serum levels of sialic acid and [gamma]-glutamyltranspeptidase (GCT)
The core glycan, mannose([alpha]1-2) mannose([alpha]1-6)mannose([alpha]1-4) glucosamine([alpha]1-6)myo-inositol is highly conserved in eukaryotes, but it can be modified with other residues such as mannose, phosphoethanolamine (Etn-P), galactose, sialic acid, and others.
Varki, "Effects of natural human antibodies against a nonhuman sialic acid that metabolically incorporates into activated and malignant immune cells," Journal of Immunology, vol.
Mwanda, "Serum total sialic acid and Hanganutziu-Deicher antibody in normals and in cancer patients," East African Medical Journal, vol.
Wiley, "Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid," Nature, vol.
Results: Serum total sialic acid concentrations were significantly higher among all diabetic subjects with or without complications compared to control subjects.
Free and total sialic acid were tested in urine considering deficiency of sialidase enzyme located in the lyososmal membrane which presents with clinical findings due to sialic acid accumulation in the tissues and urine.
The diagnostic accuracy of carbohydrate-deficient transferrin, sialic acid and commonly used markers of alcohol abuse during abstinence.
In this study we compared sensitivity, specificity and diagnostic efficiency of serum Sialic acid with other traditional markers like AST (Aspartate amino transaminase), ALT (Alanine amino transaminase), GGT (Gamma Glutamyl Transferase), as a marker of alcohol abuse.
Truncated structures included all complex N-glycans with at least 1 antenna without a terminal sialic acid (NeuNAc) and may therefore have a nonreducing end mannose, N-acetyl glucosamine (GlcNAc), or galactose (Gal).