silent mutation


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Related to silent mutation: genetic code, Nonsense mutation

silent mutation

[′sī·lənt myü′tā·shən]
(genetics)
A mutation that does not result in amino acid sequence change.
References in periodicals archive ?
EX7_ 111G/C, EX7_113G/A, EX7_117C/A, EX7_118T/A, EX7_ 119T/C, EX7_120G/A, and EX7_121delC were silent mutations. The frequencies of alleles G and H were 0.59 and 0.41, respectively, and the analyzed population was in Hardy-Weinberg equilibrium (p>0.05).
Earlier it was reported that though it is silent mutations the heterozygous EGFR mutation (G/A genotype) group showed higher sensitivity (lower IC50 values) to gefitinib than the EGFR wt (G/G genotype) group did (Hsieh et al., 2006).
CAP+1 mutation can cause serious difficulties in screening and counseling programmes in populations in which it occurs at a significant frequency.11 Such silent mutations become significant in PND for thalassaemia.20 At risk couples don\'t seek for PND if one partner is a known b thalassaemia carrier and other is apparently normal (a silent carrier), as silent carriers remain undiagnosed by routine diagnostic modalities (Blood CP, HPLC and Hb electrophoresis).
The results of cloning and sequencing showed that the mutation sites were found at codon 143 (GTG[right arrow]GTA) in two cases, which was a silent mutation; at codon 146 (TGG[right arrow]CGG) in one case, which resulted in a change from tryptophan to arginine in the protein; and at codon 151 (CCC[right arrow]TCC) in two cases, which resulted in a change from proline to serine in the protein (Figure 2).
The substitution of T/C at 35 was a silent mutation, as the mutated nucleotide does not alter the amino acid (Gly) that it encodes.
Of the HFE variants (1 in 1000 samples) T189C (6), a silent mutation, is present in 88% of the variants.
These 3 isolates from 2002 and 2003 had 11 common mutations: 2 were in env (1442 T [right arrow] C resulting in Val 449 [right arrow] Ala and 2466 C T, a silent mutation); 8 were in the NS regions (4146 A [right arrow] G in NS2A; 2 C [right arrow] T transitions at positions 4803 and 6138 in NS3; 6996C [right arrow] T and 7015T [right arrow] C in NS4B; T C transitions at positions 7938 and 8811 and 9352 C [right arrow] T at NS5); and 1 in the 3-'UTR (10851 A [right arrow] G).
Of the 4 specimens positive by DHPLC but negative by sequencing, APEX detected base changes in 3, including 1 specimen with 2 mutations (a 1-bp substitution in intron 5 and a silent mutation at codon 147; see Table 4 of the online Data Supplement).
All Haarlem strains carried one characteristic silent mutation in mutT3 and one characteristic mutation in ogt (Ser 15 replaced by Thr).
This 438G-->A sequence change is a silent mutation because both the wild-type ACA and the mutated ACG triplet encode for threonine at residue 146 of the GAMT peptide (T146T).
G3357A and T3394C are missense mutations (Met17Ileu and Tyr30His, respectively), and C3375A is a silent mutation. The patient with G3357A (case 2) had type 1 diabetes and was also positive for the anti-GAD antibody.
In addition to the G238C transition discriminating for the TPMT*2 allele, further polymorphisms are known in exon 5, one silent mutation (C339T) and one mutation that produces a stop codon (G292T), which discriminates for the TPMT*3D allelic variant (Fig.