Minor anomalies like low set ears, hypotonia, up slant or down slant of eyes, simian crease
, inner epicanthic folds were noted.
Furthermore, deviant PFC patterns, particularly the Simian crease
, have been strongly linked with chromosomal anomalies and genetic disorders, such as Down syndrome; the Sydney crease, although rarer, is associated with conditions such as fetal alcohol syndrome and craniofacial syndrome (e.g., ).
Manifestations: IUGR, failure to thrive, moderate to severe mental deficiency, hypotonia, microcephaly, bitemporal hollows, low set ears, ptosis, broad nasal tip, anteverted-nostrils, micrognathia, broad alveolar ridges, simian crease
, frequent digital whorls, "Y" shaped 2nd -3rd toe syndactyly, postaxial polydactyly.
Dermatoglyphics features like sandal gap, Kennedy line, brachydactyly, clinodactyly, polydactyly, simian crease
, Sydney line, increased ATD angle and Ulnar loop represents 42.1%, 53.2%, 37.3%, 36.5%, 4%, 33.3%, 24.6%, 40.5% and 100% cases respectively.