sinoatrial node

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Related to sinoatrial: sinoatrial block

sinoatrial node

[¦sī·nō′ā·trē·əl ′nōd]
(anatomy)
A bundle of Purkinje fibers located near the junction of the superior vena cava with the right atrium which acts as a pacemaker for cardiac excitation. Abbreviated SA node. Also known as sinoauricular node.
References in periodicals archive ?
Viewpoint: is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone?
Morris, "The anatomy and physiology of the sinoatrial node--a contemporary review," Pacing and Clinical Electrophysiology, vol.
To our knowledge, this is the first case report of recurrent profound bradycardia due to paroxysmal sinoatrial arrest in a patient treated with ibrutinib.
(a) Serious adverse events Placebo ASC P value (n = 20) (n = 40) Death 0(0) 1 (2.5) 1.00 Hospitalizations Myocardial infarction 1 (5) 1 (2.5) 1.00 Dyspnea 0 (0) 1 (2.5) 1.00 Anemia 1 (5) 1 (2.5) 1.00 Syncope 1 (5) 0(0) 0.33 Peripheral edema 0 (0) 1 (2.5) 1.00 Angina worsening 3(15) 6(15) 1.00 Pneumonia 1 (5) 1 (2.5) 1.00 NOGA-related complications Pericardial effusion 0 (0) 1 (2.5) 1.00 ECG changes-SA-block, NsVT 2 (10) 1 (2.5) 0.26 Hematoma at femoral puncture 1 (5) 0(0) 0.33 Allergic reaction 0 (0) 1 (2.5) 1.00 Bradycardia 0 (0) 1 (2.5) 1.00 General discomfort 0 (0) 1 (2.5) 1.00 NsVT: nonsustained ventricular tachycardia; SA-block: sinoatrial block.
Citation: Stephanie I Protze et al., "Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker," Nature Biotechnology, 2016; DOI: 10.1038/nbt.3745
Electrical activity is generated spontaneously via the sinoatrial node located in the right atrium, often referred to as the 'natural pacemaker' of the heart.
In a normal heart, electrical impulses start in the sinoatrial node near the top of the right atrium, causing the atria to contract and send blood down to the heart's ventricles (lower chambers).
This depolarizes a critical mass of the heart muscle, terminates the dysrhythmia and allows normal sinus rhythm to be reestablished by the body's natural pacemaker, in the sinoatrial node of the heart.
Caution is required in cases of sympotmat cardiac rhythm disorders, sinoatrial or antrioventricular conduction disorders.
Ivabradine (Corlanor, Amgen) is a sinoatrial node modulator.
Not to mention the cell loss at the sinoatrial node and subsequent heart rate disorders.