Group E served as experimental group and was given sodium cyclamate 60mg/kg/day through oral gavage tube for two months.
Conclusion: Sodium cyclamate affects the histomorphology of endocrine pancreas by increasing the area of islets of langerhans in treated group.
Sodium cyclamate is used as an artificial sweetener in many foods, beverages as well as medicines due to its odorless nature and solubility in water, propylene glycol and alcohol.
However, in 1977, the Committee on Food Additives at the World Health Organization (WHO), approved the use of sodium cyclamate as a food additive in more than 40 countries (Boop et al., 1986) including Brazil (Ahmed & Thomas), although experimental results present reasons for its non-utilization.
(1970), sodium cyclamate crosses the placental barrier approaching a fetal concentration of this substance equivalent to one quarter of the existent maternal concentration.
The objective of the present study will be to evaluate placental morphometric alterations detected in rats submitted to intraperitoneal administration of sodium cyclamate from the tenth to fourteenth day of pregnancy, in the following manner:
The objective of this study was to evaluate fetal hepatic karyometric and stereological alterations in the rat fetal liver resulting from the intraperitoneal administration of sodium cyclamate. The livers of ten rats were evaluated, five treated and five controls chosen at random, in which five rats that received from the 10th to 14th days of pregnancy an intraperitoneal daily injection of sodium cyclamate at 60 mg/Kg of body weight during 5 days.
KEY WORDS: Sodium cyclamate; Fetal iiver; Karyometry; Stereology.
However, the World Health Organization's Joint Expert Committee on food Additives approved the use of sodium cyclamate in 1977, as an alimentary additive in more than 40 countries including Brazil (Boop et al., 1986; Ahmed & Thomas), although several experimental results from that era presented reasons for its non-utilization (Oser et al., 1968; Pitkin et al., 1970; Kroes et al., 1977).
EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY
The purpose of this research was to assess the effect of sodium cyclamate in kidneys of rats fetuses considering morphometric changes of glomerulus, proximal and distal convoluted tubules, and collecting duct.
The composition of the product appears in different forms: sodium cyclamate, calcium cyclamate and cyclamic acid (Cattanach, 1976).