soft electrophile

soft electrophile

[′sȯft i′lek·trə‚fīl]
(physical chemistry)
A molecule that readily accepts electrons during a primary reaction step.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In this review, we discuss the chemical nature of ACR (a soft electrophile) and how this determines the corresponding sites of protein adduction (soft nucleophilic sulfhydryl thiolates on cysteine residues).
The unsaturated carbonyl structure of ACR is a soft electrophile that will preferentially form Michael-type adducts with soft nucleophiles, which in biological systems are sulfhydryl side-chains on cysteine residues.
We also show how application of the hard and soft, acids and bases (HSAB) theory led to the recognition that the [alpha], [beta]-unsaturated carbonyl structure of ACR is a soft electrophile that preferentially forms covalent bonds with soft nucleophiles.