An immunohistochemical study of metaplastic spindle cell carcinoma
, phyllodes tumor and fibromatosis of the breast.
Mucinous tubular and spindle cell carcinoma
of kidney is probably a variant of papillary renal cell carcinoma with spindle cell features.
The various terminologies (sarcomatoid carcinoma, carcinosarcoma, pseudosarcoma, pseudosarcomatous squamous cell carcinoma, spindle cell carcinoma
, and polypoid carcinoma) reflect the uncertain histogenesis of this tumor.
Low-grade spindle cells can be seen in mucinous tubular spindle cell carcinoma
and occasionally clear cell carcinoma.
2) The pure form of spindle cell carcinoma
15) Mucinous tubular and spindle cell carcinoma
of the kidney is a rare renal neoplasm that may show significant morphologic and immunohistochemical overlap with our case.
The 1981 World Health Organization's Histological Typing of Lung Tumours (12) recognized spindle cell carcinoma
as a variant of squamous cell carcinoma; giant cell carcinoma as a variant of large cell carcinoma; and carcinosarcoma and pulmonary blastoma as miscellaneous malignant tumors.
Taken together, we believe the transformed lesion in this patient represents an anaplastic carcinoma with spindled elements (eg, spindle cell carcinoma
, carcinosarcoma, or metaplastic carcinoma).
Atypical fibroxanthoma is negative for keratin, S100, and HMB-45; however, not all spindle cell carcinomas
stain positively for keratin, and spindle cell or desmoplastic melanoma may rarely be negative for S100 and HMB-45.
Finally, spindle cell carcinoma
can be ruled out by its positivity for cytokeratin and negativity for CD34.
1-5] The differential diagnosis for pleural spindle cell neoplasms includes smooth muscle tumors, malignant mesothelioma, thymoma, spindle cell carcinoma
, and other soft tissue tumors arising in the adjacent organs, as well as solitary fibrous tumor in cases of circumscribed masses.
Online access to ten videos covering the treatment of squamous and spindle cell carcinomas