By oneway Anova test, it was found that there was significant difference in degeneration grades of all parameters (organ of corti, spiral ganglion
, and stria vascularis) among the three groups (p<0.05).
In vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion
," Hearing Research, vol.
"These findings are particularly interesting as they show that spiral ganglion
stem cells can be propagated in vitro," Bioresearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland said in a news release.
Marc Diensthuber and coauthors from Goethe-University (Frankfurt, Germany), Justus-Liebig University (Giessen, Germany), Harvard Medical School and Massachusetts Eye and Ear Infirmary (Boston, MA), and Harvard University and MIT (Cambridge, MA), conclude that the self-renewing properties demonstrated by spiral ganglion
stem cells make them a promising source of replacement cells for therapies designed to regenerate the neural structures of the inner ear in the article "Spiral Ganglion
Stem Cells Can Be Propagated and Differentiated Into Neurons and Glia"
This site of activation is assumed to be the cell bodies of spiral ganglion
neurons or, in some cases, surviving peripheral nerve fibers within the osseous spiral lamina.
We believe that the studies included in this second special issue of "Hearing Loss: Reestablish the Neural Plasticity in Regenerated Spiral Ganglion
Neurons and Sensory Hair Cells" provide important insights into cochlear physiology and pathology as well as the important progress in technology that can be translated into clinical application of the medical treatment of cochlear damage in SNHL.
Methodological Aspects of Quantitative Study of Spiral Ganglion
In P0-P14 mouse cochleae, IBA1+ cells were mainly observed in the modiolus, spiral lamina, spiral ganglion
, spiral ligament, and the organ of Corti (Figure 1).
neurons in the ear convert mechanical sound vibrations into electrical signals that the brain interprets as sound.
(87) The primary peripheral target appears to be the neurons in the spiral ganglion
. The lead author's laboratory studied the effects of a broad-spectrum glutamate receptor antagonist, kynurenic acid (KYNA), on glutamate- and noise-induced trauma in guinea pigs.
Third, the specific region of activation within the spiral ganglion
is determined by the shape of the carrier and the position of the contacts on the surface of the carrier.
In the cochlea, the neurons of the spiral ganglion
emit peripheral processes that extend to the organ of Corti and have central processes that project to the cochlear nuclei via the auditory nerve.